PLOD3

  • Official Full Name

    procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3

  • Overview

    The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity.

  • Synonyms

    PLOD3;procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3;procollagen-lysine,2-oxoglutarate 5-dioxygenase 3;LH3;lysyl hydroxlase 3;2-oxoglutarate 5-dioxygenase 3;Lysine hydroxylase 3;Lysyl hydroxylase 3;PLOD3_HUMAN;Procollagen lysine,2 oxoglutarate 5 dioxygenase 3 precursor;Procollagen-lysine

Recombinant Proteins

  • Human
  • Mouse
  • Zebrafish
  • Rat
  • E.coli
  • Mammalian Cells
  • HEK293
  • His
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
PLOD3-1794H Recombinant Human PLOD3, His-tagged E.coli Human His C-term-400aa
PLOD3-12986M Recombinant Mouse PLOD3 Protein Mammalian Cells Mouse His
PLOD3-3882Z Recombinant Zebrafish PLOD3 Mammalian Cells Zebrafish His
PLOD3-4530R Recombinant Rat PLOD3 Protein Mammalian Cells Rat His
PLOD3-1379HCL Recombinant Human PLOD3 cell lysate Human Non
PLOD3-4190R Recombinant Rat PLOD3 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
PLOD3-4190R-B Recombinant Rat PLOD3 Protein Pre-coupled Magnetic Beads HEK293 Rat
PLOD3-5052H Recombinant Human PLOD3 protein, His-tagged HEK293 Human His 25-738aa
PLOD3-6857M Recombinant Mouse PLOD3 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
PLOD3-6857M-B Recombinant Mouse PLOD3 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    PLOD3 involved in several pathways and played different roles in them. We selected most pathways PLOD3 participated on our site, such as Lysine degradation,Other types of O-glycan biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLOD3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Lysine degradation GCDH,PIPOX,SUV420H2,OGDHL,HYKK.2,ALDH3A2A,SETDB1B,ACAT1,HADH,MLL1
    Other types of O-glycan biosynthesis GXYLT1,FUT9A,B3GAT2,ST6GAL1,B4GALT1,B3GAT1A,GLT25D1,B4GALT3,POMT2,B3GALTLB

    Protein Function

    PLOD3 has several biochemical functions, for example, L-ascorbic acid binding,iron ion binding,procollagen galactosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PLOD3 itself. We selected most functions PLOD3 had, and list some proteins which have the same functions with PLOD3. You can find most of the proteins on our site.

    Function Related Protein
    protein binding MAPK15,CRTAC1,2610109H07Rik,CLN5,Ctsl,RUNX2,CRP,SCNN1G,ZNF410,EPN3
    L-ascorbic acid binding EGLN3,PLOD1A,P4HA3,FAM125B,TMLHE,P4HTM,OGFOD2,PLOD2,PAM,OGFOD3
    iron ion binding CYP3A5,CYP4T8,CYP7A1,PPEF2,NOS1,CYP2U1,TH2,P4HA3,SCD,CYP2F1
    procollagen glucosyltransferase activity FAM125B
    procollagen galactosyltransferase activity GLT25D1,FAM125B,GLT25D2,COLGALT2
    procollagen-lysine 5-dioxygenase activity FAM125B,PLOD1,PLOD2,PLOD1A

    Interacting Protein

    PLOD3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLOD3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLOD3.

    EHMT2;EFHC2;RAB3IP;RHOXF2;4505953;TECPR1;CCDC85B;DPPA2;EHMT2;ssdna_dc;MYC;cona_canen;ESR1

    Resources

    Research Area

    ECM Regulators

    References

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