PLEKHA1
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Official Full Name
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 -
Overview
This gene encodes a pleckstrin homology domain-containing adapter protein. The encoded protein is localized to the plasma membrane where it specifically binds phosphatidylinositol 3,4-bisphosphate. This protein may be involved in the formation of signaling complexes in the plasma membrane. Polymorphisms in this gene are associated with age-related macular degeneration. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5. -
Synonyms
PLEKHA1;pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1;pleckstrin homology domain-containing family A member 1;tandem PH domain containing protein 1;TAPP1;OTTHUMP00000020651;PH domain containing family A member 1;Pleckstrin homology domain containing family A member 1;Pleckstrin homology domain containing, family A (phosphoinositide binding specific) member;TAPP 1;OTTHUMP00000020650;OTTHUMP00000206097;tandem PH domain-containing protein 1
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- T7
- DDK
- Myc
- Avi
- Fc
Involved Pathway
PLEKHA1 involved in several pathways and played different roles in them. We selected most pathways PLEKHA1 participated on our site, such as B Cell Receptor Signaling Pathway,Class I PI3K signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLEKHA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Class I PI3K signaling events | ITK,ADAP1,ARF1,BLK |
| B Cell Receptor Signaling Pathway | NFATC2,ARPC3,CMTM3,ACTR3,CR2,HDAC5,PIK3CG,PPP3R2,PIK3R1,RAF1 |
Protein Function
PLEKHA1 has several biochemical functions, for example, PDZ domain binding,phosphatidylinositol-3,4-bisphosphate binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PLEKHA1 itself. We selected most functions PLEKHA1 had, and list some proteins which have the same functions with PLEKHA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| PDZ domain binding | DTNA,GRID2,FZD3,NSF,LIN7C,ERC1,PSEN1,LLGL2,LPAR2,GNG12 |
| protein binding | SMARCC1,TTC12,PPARG,GDI2,PPP1R9A,ATP6V0C,RECK,THAP10,ASPSCR1,FAM117B |
| phosphatidylinositol-3,4-bisphosphate binding | PLEK,GAB2,KIF16B,ZFYVE1,NCF1,ADAP2,COMMD1,RS1,ARAP3,PHLDA3 |
Interacting Protein
PLEKHA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLEKHA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLEKHA1.
MPDZ;PTPN13;SH3BP4;CRKL;queA;pi3p;Lats2
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