PLCE1
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Official Full Name
Phospholipase C epsilon 1 -
Overview
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation. -
Synonyms
1-phosphatidylinositol-4;5-bisphosphate phosphodiesterase epsilon-1;Pancreas-enriched phospholipase C;Phosphoinositide phospholipase C-epsilon-1;Phospholipase C-epsilon-1;PLC-epsilon-1;Plce1;PLCE1
Recombinant Proteins
- Mouse
- Rat
- Human
- Zebrafish
- E.coli
- Mammalian Cells
- HEK293
- His&T7
- His
- Myc&DDK
- His&GST
- His&Fc&Avi
- Flag
Involved Pathway
PLCE1 involved in several pathways and played different roles in them. We selected most pathways PLCE1 participated on our site, such as Inositol phosphate metabolism,Metabolic pathways,Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLCE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ras signaling pathway | GRIN2A,PLA2G4D,PIK3CG,RRAS2,FGF12,ETS2,KIT,PIK3R3,KSR1,RASAL2 |
| Thyroid hormone signaling pathway | RAF1,MAPK3,PRKCB,FXYD2,NOTCH4,ATP1B1,NOTCH3,ATP1B2,NRAS,CCND1 |
| cAMP signaling pathway | PTGER3,MAP2K1,HTR6,PIK3CD,ROCK1,RAP1A,CAMK2G,ORAI1,PRKACA,TNNI3 |
| Calcium signaling pathway | ITPKB,CALM1,TNNC1A,HRH1,ATP2B3B,P2RX3A,ORAI1B,DRD1B,CAMK2A,TNNC1 |
| Rap signaling pathway | PARD6A,CDH1,GNAS,MAPK12,PLCB2,NRAS,MAP2K3,RHOA,MAGI1,DOCK4 |
| Metabolic pathways | ALOX12B,PTGES3A,PIGP,GCDH,AGXT2,CMAS,Atp5g2,P4HA1,CPS1,UGT8A |
| Phosphatidylinositol signaling system | MTMR2,PLCB4,PLCD4,PLCD1B,PIP5K1AA,CALM,PIP5K1A,PIK3R5,PIP5K2,MTM1 |
| Inositol phosphate metabolism | ISYNA1,INPP5B,PI4K2B,PLCB3,PLCD1B,NUDT4A,PTEN,NUDT3A,MTMR6,CDIPT |
| Proteoglycans in cancer | FLNA,ANK2,IL12B,HOXD10,ITGB1,SMAD2,Ctsl,FZD5,PLCG1,PRKCA |
Protein Function
PLCE1 has several biochemical functions, for example, Ras GTPase binding,enzyme binding,guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PLCE1 itself. We selected most functions PLCE1 had, and list some proteins which have the same functions with PLCE1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| enzyme binding | ZFP346,PRKCD,HSPA2,HDAC6,MTA1,RAC1,CASC3,VAPB,DDX5,PRKCE |
| phospholipase C activity | ADORA1,PLCG2,PLCL1,PLCB4,PLCB2,PLCH2,PLCG1,PDIA3,PLCB3 |
| protein binding | CDC23,VAT1L,GZMB,MYL6,FLI1,PDZD3,TSPO,CHAMP1,ZFP746,AURKAIP1 |
| Ras GTPase binding | RAPGEF4,SH3BP4,MAP2K1,RGL3,RIN1,CIB1,SPHK2,RAPGEF6,RASGRP3,MLLT4 |
| receptor signaling protein activity | BAG1,CD3E,ARAF,TRAIP,RAF1A,NSMAF,FLRT3,KLK1B4,SMAD1,ADCYAP1 |
| guanyl-nucleotide exchange factor activity | DOCK5,RALGPS2,RASGRP3,GAPVD1,DOCK6,ARHGEF39,RALGPS1,VAV2,SH2D3A,RAPGEF6 |
| phosphatidylinositol phospholipase C activity | CHRM5,PLCD1A,PLCH2,CCR1,PLCB3,CHRM1,PLCZ1,CASR,PLCB4,PLCD1 |
Interacting Protein
PLCE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLCE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLCE1.
NRAS;LIMS1;HSP90AA1
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