PLAGL1

  • Official Full Name

    pleiomorphic adenoma gene-like 1

  • Overview

    This gene encodes a C2H2 zinc finger protein with transactivation and DNA-binding activities. It has been shown to have anti-proliferative properties, and thus thought to function as a tumor suppressor. In addition, overexpression of this gene during fetal development is believed to underlie the rare disorder, transient neonatal diabetes mellitus (TNDM). This gene is imprinted, with preferential expression of the paternal allele in many tissues, however, biallelic expression has been noted in peripheral blood leucocytes. A recent study reports that tissue-specific imprinting results from variable utilization of monoallelic and biallelic promoters. Many transcript variants differing in the 5 UTR and encoding two different isoforms, have been found for this gene. [provided by RefSeq, Oct 2010]

  • Synonyms

    PLAGL1;pleiomorphic adenoma gene-like 1;ZAC;LOT1;ZAC1;zinc finger protein PLAGL1;LOT-1;PLAG-like 1;tumor supressor ZAC;tumor suppressor ZAC;lost on transformation 1;pleiomorphic adenoma-like protein 1

Recombinant Proteins

  • Human
  • Rhesus macaque
  • Mouse
  • Rat
  • E.coli
  • Wheat Germ
  • Mammalian Cells
  • HEK293
  • His
  • HIS
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
PLAGL1-3585H Recombinant Human PLAGL1 protein, His-tagged E.coli Human His 201-463 aa
PLAGL1-752H Recombinant Human PLAGL1 Protein, His-tagged E.coli Human His His226~Pro362
PLAGL1-069H Recombinant Human PLAGL1 Protein, HIS-tagged E.coli Human HIS
PLAGL1-31027TH Recombinant Human PLAGL1 Wheat Germ Human Non 100 amino acids
PLAGL1-3460R Recombinant Rhesus monkey PLAGL1 Protein, His-tagged Mammalian Cells Rhesus macaque His
PLAGL1-3133HCL Recombinant Human PLAGL1 293 Cell Lysate HEK293 Human Non
Plagl1-1946M Recombinant Mouse Plagl1 Protein, His-tagged E.coli Mouse His Phe4-Met212
Plagl1-1947R Recombinant Rat Plagl1 Protein, His-tagged E.coli Rat His Phe4-Met212
PLAGL1-3278R Recombinant Rhesus Macaque PLAGL1 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
PLAGL1-3278R-B Recombinant Rhesus Macaque PLAGL1 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque

    Involved Pathway

    PLAGL1 involved in several pathways and played different roles in them. We selected most pathways PLAGL1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PLAGL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    Protein Function

    PLAGL1 has several biochemical functions, for example, DNA binding,RNA polymerase II regulatory region sequence-specific DNA binding,RNA polymerase II transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PLAGL1 itself. We selected most functions PLAGL1 had, and list some proteins which have the same functions with PLAGL1. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II transcription factor activity, sequence-specific DNA binding KLF11,FOXA1,FOXD4L1,PAX6B,NHLH2,RUNX3,ZNF18,FOXP1,HIF1AB,ELF2B
    RNA polymerase II regulatory region sequence-specific DNA binding ZNF584,ONECUT3,ZNF549,MYOG,PURB,ZBTB11,RELA,ACTN4,ETV6,NME2
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding EAF2,ATF1,CEBPA,ESRRG,HSF2,CSRNP3,HOXD8,MSGN1,CREB3L4,GATA5
    metal ion binding CYB561D1,GDPD4,PAN3,KCNIP3B,ZKSCAN14,CACNA1H,DGKQ,MCCC1,ING5B,U2AF1L4
    DNA binding RXRAB,ZFP260,SUPV3L1,VPS72,DLX4B,C5orf20,SOS1,CXXC1A,CEBPG,ZNF461

    Interacting Protein

    PLAGL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLAGL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLAGL1.

    SMAD3

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