PLAG1

  • Official Full Name

    pleiomorphic adenoma gene 1

  • Overview

    Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals. PLAG1, which is developmentally regulated, has been shown to be consistently rearranged in pleomorphic adenomas of the salivary glands. PLAG1 is activated by the reciprocal chromosomal translocations involving 8q12 in a subset of salivary gland pleomorphic adenomas. Three transcript variants encoding two different isoforms have been found for this gene.

  • Synonyms

    PLAG1;pleiomorphic adenoma gene 1;zinc finger protein PLAG1;ZNF912;FGFR1/PLAG1 fusion variant 3;PLAG1_HUMAN;Pleiomorphic adenoma gene 1 protein;PSA;SGPA;OTTHUMP00000226422;OTTHUMP00000226423;OTTHUMP00000226424;COL1A2/PLAG1 fusion

Recombinant Proteins

  • Human
  • Mouse
  • Chicken
  • Zebrafish
  • Rat
  • E.coli
  • Mammalian Cells
  • Wheat Germ
  • HEK293
  • His
  • Non
  • GST
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
PLAG1-1762H Recombinant Human PLAG1, His-tagged E.coli Human His 151-500aa
PLAG1-2781H Recombinant Human PLAG1 protein, His-tagged E.coli Human His 1-75 aa
PLAG1-12909M Recombinant Mouse PLAG1 Protein Mammalian Cells Mouse His
PLAG1-31026TH Recombinant Human PLAG1 Wheat Germ Human Non 98 amino acids
PLAG1-3218C Recombinant Chicken PLAG1 Mammalian Cells Chicken His
PLAG1-3657Z Recombinant Zebrafish PLAG1 Mammalian Cells Zebrafish His
PLAG1-4493R Recombinant Rat PLAG1 Protein Mammalian Cells Rat His
PLAG1-3134HCL Recombinant Human PLAG1 293 Cell Lysate HEK293 Human Non
PLAG1-301522H Recombinant Human PLAG1 protein, GST-tagged E.coli Human GST Met1-Ser75
PLAG1-4153R Recombinant Rat PLAG1 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
PLAG1-4153R-B Recombinant Rat PLAG1 Protein Pre-coupled Magnetic Beads HEK293 Rat
PLAG1-6810M Recombinant Mouse PLAG1 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
PLAG1-6810M-B Recombinant Mouse PLAG1 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    PLAG1 involved in several pathways and played different roles in them. We selected most pathways PLAG1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PLAG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    Protein Function

    PLAG1 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,RNA polymerase II transcription factor activity, sequence-specific DNA binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PLAG1 itself. We selected most functions PLAG1 had, and list some proteins which have the same functions with PLAG1. You can find most of the proteins on our site.

    Function Related Protein
    metal ion binding MB21D1,LIMCH1B,ASAP2,ZBED2,ZFYVE28,ZNF654,PLA2G12B,NME4,ZNRF2A,ATP2C2
    RNA polymerase II core promoter proximal region sequence-specific DNA binding TFE3A,SMAD1,GCM1,NR1H2,MEIS1,DDN,GMEB1,ZNF257,TP73,BSX
    transcription factor activity, sequence-specific DNA binding SOX2,SALL3,ZNF812,PFDN1,TSC22D2,AHCTF1,HSFY1,EVX1,ZNF577,DMRT3A
    RNA polymerase II transcription factor activity, sequence-specific DNA binding SOX9A,HIF1AL2,FOXM1,FOXD4,KLF11,FOXA1,MEF2D,EF1,CC2D1B,RUNX2A
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding TTC6,NEUROD1,NFIC,POU2F3,TP63,TCF21,ATF2,KLF15,FIGLA,FLI1

    Interacting Protein

    PLAG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLAG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLAG1.

    SMAD3;q8czt4_yerpe;ALB

    Resources

    References

    • Matsuyama, A; Hisaoka, M; et al. Aberrant PLAG1 expression in pleomorphic adenomas of the salivary gland: a molecular genetic and immunohistochemical study. VIRCHOWS ARCHIV 458:583-592(2011).
    • Uro-Coste, E; et al. 2009 update in salivary gland tumoral pathology. ANNALES DE PATHOLOGIE 29:274-285(2009).

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