PKLR
-
Official Full Name
pyruvate kinase, liver and RBC -
Overview
The protein encoded by this gene is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA). Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
PKLR;pyruvate kinase, liver and RBC;pyruvate kinase isozymes R/L;pyruvate kinase 1;pyruvate kinase type L;pyruvate kinase isozyme R/L;R-type/L-type pyruvate kinase;red cell/liver pyruvate kinase;pyruvate kinase, liver and blood cell;PK1;PKL;PKR
Recombinant Proteins
- Rabbit
- Zebrafish
- Human
- Mouse
- Rat
- Rabbit Muscle
- Mammalian Cells
- Human
- E.coli
- HEK293
- Yeast
- Non
- His
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
PKLR involved in several pathways and played different roles in them. We selected most pathways PKLR participated on our site, such as Glycolysis / Gluconeogenesis,Purine metabolism,Pyruvate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PKLR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Type II diabetes mellitus | CACNA1G,HK3,SOCS1,INS,PIK3CA,PIK3CG,SOCS3,IRS4,SLC2A2,MAPK1 |
| Purine metabolism | POLR1A,CECR1A,XDH,GC3,CANT1B,ENTPD2A.1,NME7,URAH,POLR2B,NT5C3A |
| Maturity onset diabetes of the young | MAFA,FOXA3,NKX6-1,INS,MNX1,PAX6,NR5A2,HNF1B,NKX6,IAPP |
| Non-alcoholic fatty liver disease (NAFLD) | EIF2AK3,SDHC,PIK3R3,NDUFA11,ATF4,PIK3R1,AKT2,NDUFA5,SDHD,TNF |
| Glycolysis / Gluconeogenesis | HK2,HKDC1,ADH6,PGAM2,ADH1B,PGK2,LDHAL6B,FBP1A,PFKMB,ADH1 |
| Pyruvate metabolism | ALDH2,PDHA2,PKM2,PDK2B,ALDH3A2A,ACOT12,GRHPRA,PCK1,GLO1,FH |
| Biosynthesis of amino acids | GOT2B,MAT1A,ALDOCB,IDH3A,PFKM,PRPS1,TALDO1,TPI1,OTC,PGAM1B |
| Carbon metabolism | PGK1,AGXTB,TPI1,PDHA2,GPI,FBP1B,PDHB,HK3,HIBCH,ACO2 |
| Insulin signaling pathway | HRAS,CALM1B,INS1,MKNK2B,PIK3CB,INSRB,MAPK10,PRKAG2A,PIK3CA,FBP2 |
Protein Function
PKLR has several biochemical functions, for example, ATP binding,kinase activity,magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PKLR itself. We selected most functions PKLR had, and list some proteins which have the same functions with PKLR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| pyruvate kinase activity | PKMB,PKM2,PKMA,PKM |
| kinase activity | MAPK8B,PDXKB,GRK1B,GM4922,PFKFB2A,GM7168,SBK1,PRKACBA,NEK4,EPHA2A |
| potassium ion binding | SLC24A5,PKM,KCNJ11,SLC24A4A,PKMB,PKM2,PDXK,HDAC4,SLC24A4,PKMA |
| ATP binding | LACE1A,PI4K2A,GNE,NEK7,FLAD1,EEF2K,MYO6B,TTF2,UBE2J2,ACTB2 |
| magnesium ion binding | PGM5,ARF1,DUT,CIB4,PTEN,PPM1A,ATP8B3,IRAK3,ICK,ADPRHL1 |
Interacting Protein
PKLR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PKLR here. Most of them are supplied by our site. Hope this information will be useful for your research of PKLR.
USPL1;OTUD5;USP3;CLEC4G;ere_dna;ANXA1
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References
- Zheng, L; Feng, YH; et al. Intralipid Decreases Apolipoprotein M Levels and Insulin Sensitivity in Rats. PLOS ONE 9:-(2014).
- Grahn, RA; Grahn, JC; et al. Erythrocyte Pyruvate Kinase Deficiency mutation identified in multiple breeds of domestic cats. BMC VETERINARY RESEARCH 8:-(2012).
