PKD2
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Official Full Name
polycystic kidney disease 2 (autosomal dominant) -
Overview
As members of the calcium-/calmodulin-depedent protein kinase superfamily, there are three known Protein Kinase D receptor in stably-transfected AGS-B cells. Furthermore, PKD2 is found to be active during the early phase of differentation of C2C12 cells into skeletal muscle cells. It is also reported to enhance TCR-induced NFAT activity in Jurkat T cells. -
Synonyms
PKD2;polycystic kidney disease 2 (autosomal dominant);polycystin-2;Pc 2;PC2;PKD4;transient receptor potential cation channel;subfamily P;member 2;TRPP2;R48321;polycystwin;autosomal dominant polycystic kidney disease type II protein;transient receptor potential cation channel, subfamily P, member 2;Pc-2;APKD2;MGC138466;MGC138468
Recombinant Proteins
- Human
- Mouse
- Chicken
- Zebrafish
- E.coli
- Mammalian Cells
- Wheat Germ
- Sf9 Cells
- HEK293
- GST
- His
- Non
- Flag
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PKD2-19H | Recombinant Human PKD2 Protein, GST-tagged | E.coli | Human | GST | 682-923 aa | |
| PKD2-12860M | Recombinant Mouse PKD2 Protein | Mammalian Cells | Mouse | His |
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| PKD2-2812C | Recombinant Chicken PKD2 | Mammalian Cells | Chicken | His |
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| PKD2-30689TH | Recombinant Human PKD2 | Wheat Germ | Human | Non | 100 amino acids |
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| PKD2-410H | Recombinant Human PKD2, GST-tagged, Active | Sf9 Cells | Human | GST |
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| PKD2-459Z | Recombinant Zebrafish PKD2 | Mammalian Cells | Zebrafish | His |
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| PKD2-660H | Recombinant Human Polycystic Kidney Disease 2 (Autosomal Dominant) | E.coli | Human | Non |
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| PKD2-1184HFL | Recombinant Human PKD2 protein, His&Flag-tagged | HEK293 | Human | Flag&His | 1-968 aa |
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| PKD2-6779M | Recombinant Mouse PKD2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| PKD2-6779M-B | Recombinant Mouse PKD2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
PKD2 involved in several pathways and played different roles in them. We selected most pathways PKD2 participated on our site, such as Assembly of the primary cilium,Cargo trafficking to the periciliary membrane,Organelle biogenesis and maintenance, which may be useful for your reference. Also, other proteins which involved in the same pathway with PKD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Assembly of the primary cilium | TTC30A1,CEP135,ARF4,TTC30A2,CLUAP1,EXOC8,IFT122,CCDC41,IFT52,DYNLL2A |
| Organelle biogenesis and maintenance | ARF4A,CNGA5,IFT46,GFM2,GADD45GIP1,BBS12,MRPS25,MRPL47,MRPS26,FBF1 |
| Cargo trafficking to the periciliary membrane | UNC119B,CCT3,UNC119.1,ARL3,BBS7,LZTFL1,EXOC8,ARL13B,CYS1,BBS9 |
| VxPx cargo-targeting to cilium | ARF4,ARF4A,CNGA2,PKD1,RAB3IP,CNGA5 |
Protein Function
PKD2 has several biochemical functions, for example, ATPase binding,HLH domain binding,actinin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PKD2 itself. We selected most functions PKD2 had, and list some proteins which have the same functions with PKD2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| actinin binding | PROM1,CSRP3,RELA,PDLIM5,NFKB1,MICALL2,TTN |
| voltage-gated ion channel activity | CACNG2B,KCNJ1A.6,CLIC4,ANO6,CACNA1BA,GPR89,SCN4AA,CLIC5B,KCNJ1A.1,KCNJ1A.3 |
| HLH domain binding | UBE2I,SIRT1 |
| muscle alpha-actinin binding | NRAP,LDB3,MYPN,PDLIM2,PKD2L1,PALLD,TTN |
| potassium channel activity | KCNIP3,KCNC3A,KCNK5,KCNIP4,KCNK5A,KCNK10B,KCNS3B,KCNF1A,KCNK13B,KCNK1 |
| protein homodimerization activity | CAMK2D,LDB1,DMRT2A,TYRP1,DROSHA,ABCG2,TOX3,CIB2,HSD17B4,NDP |
| calcium ion binding | CASQ1B,DLA,CDH3,MMP15,MYL12.1,S100B,ANXA11B,EML1,PCDH12,KCNIP3A |
| cytoskeletal protein binding | EPB41L4B,MSNA,MYLIP,PTPN4A,FABP3,PDLIM3,FLNC,ABI1,PTPN4,FARP2 |
| calcium-induced calcium release activity | RYR2,RYR3 |
Interacting Protein
PKD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PKD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PKD2.
PKD1;TRPC1
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References
- Armacki, M; Joodi, G; et al. A novel splice variant of calcium and integrin-binding protein 1 mediates protein kinase D2-stimulated tumour growth by regulating angiogenesis. ONCOGENE 33:1167-1180(2014).
- Streets, AJ; Wessely, O; et al. Hyperphosphorylation of polycystin-2 at a critical residue in disease reveals an essential role for polycystin-1-regulated dephosphorylation. HUMAN MOLECULAR GENETICS 22:1924-1939(2013).
