PIWIL1
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Official Full Name
piwi-like RNA-mediated gene silencing 1 -
Overview
This gene encodes a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. The encoded protein may play a role as an intrinsic regulator of the self-renewal capacity of germline and hematopoietic stem cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010] -
Synonyms
PIWIL1;piwi-like RNA-mediated gene silencing 1;HIWI;MIWI;PIWI;CT80.1;piwi-like protein 1;piwi homolog
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Chicken
- Zebrafish
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- His
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PIWIL1-1736H | Recombinant Human PIWIL1, His-tagged | E.coli | Human | His | N-term-350aa | |
| PIWIL1-12852M | Recombinant Mouse PIWIL1 Protein | Mammalian Cell | Mouse | His |
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| PIWIL1-33H | Recombinant Human PIWIL1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| PIWIL1-3443R | Recombinant Rhesus monkey PIWIL1 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| PIWIL1-3714C | Recombinant Chicken PIWIL1 | Mammalian Cell | Chicken | His |
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| PIWIL1-9698Z | Recombinant Zebrafish PIWIL1 | Mammalian Cell | Zebrafish | His |
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| PIWIL1-1359HCL | Recombinant Human PIWIL1 cell lysate | Human | Non |
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| PIWIL1-3261R | Recombinant Rhesus Macaque PIWIL1 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| PIWIL1-3261R-B | Recombinant Rhesus Macaque PIWIL1 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| PIWIL1-6772M | Recombinant Mouse PIWIL1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| PIWIL1-6772M-B | Recombinant Mouse PIWIL1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
PIWIL1 involved in several pathways and played different roles in them. We selected most pathways PIWIL1 participated on our site, such as Dorso-ventral axis formation, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIWIL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Dorso-ventral axis formation | SPIRE2,GRB2A,ETV7,GRB2,MAPK1,NOTCH1B,ETV6,PIWIL2,CPEB2,ETS1 |
Protein Function
PIWIL1 has several biochemical functions, for example, mRNA binding,piRNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIWIL1 itself. We selected most functions PIWIL1 had, and list some proteins which have the same functions with PIWIL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| piRNA binding | PIWIL4,PIWIL2 |
| protein binding | ANKRD1,LINC00482,CLK1,MKI67,CIB4,BCR,VIP,EIF1AX,UBQLN2,MOCS3 |
| protein kinase binding | TPX2,ITGB1BP1,ARHGEF7,AGAP2,LCK,DNAJA3,GCSAM,CDK5,BCL10,CHRNA7 |
| single-stranded RNA binding | CBX4,TLR7,DLX2,LSM14A,IFIT5,SNRPC,TLR8,ENDOV,DHX58,HNRNPF |
| mRNA binding | CSTF2T,CLUHA,ELAVL1,EIF4A1,SRRM4,HSP26,LUC7L2,RBFOX1L,RC3H2,TRA2B |
Interacting Protein
PIWIL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIWIL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIWIL1.
DICER1;b4dyc6_human;HSP90AA1;HSF2;FKBP5;PTGES3;HSP90AB1;NUDCD3;q96be0_human;PPP5C;CACYBP;NUDC
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