PION
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Official Full Name
pigeon homolog -
Overview
Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer disease (AD; MIM 104300). Formation of;amyloid-beta is catalyzed by gamma-secretase (see PSEN1; MIM 104311), a protease with numerous substrates. PION, or;GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both;gamma-secretase and its substrate, the amyloid-beta precursor protein (APP; MIM 104760) C-terminal fragment (APP-CTF);(He et al., 2010 (PubMed 20811458)). -
Synonyms
PION;pigeon homolog (Drosophila);gamma-secretase-activating protein;LOC54103;protein pigeon homolog;GSAP;MGC126548;DKFZp667B242
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PION-12823M | Recombinant Mouse PION Protein | Mammalian Cell | Mouse | His |
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| PION-6751M | Recombinant Mouse PION Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| PION-6751M-B | Recombinant Mouse PION Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
PION involved in several pathways and played different roles in them. We selected most pathways PION participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PION were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
PION has several biochemical functions, for example, beta-amyloid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PION itself. We selected most functions PION had, and list some proteins which have the same functions with PION. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| beta-amyloid binding | CLSTN1,SORL1,APBA3,TGFB2,HSD17B10,Apba1,APOA1,ACHE,ARMCX5-GPRASP2,OLFM1 |
Interacting Protein
PION has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PION here. Most of them are supplied by our site. Hope this information will be useful for your research of PION.
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