PILRB
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Official Full Name
paired immunoglobin-like type 2 receptor beta -
Overview
Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the non-ITIM-bearing member of the receptor pair, which has a truncated cytoplasmic tail relative to its ITIM-bearing partner, and functions in the activating role. Alternatively spliced transcript variants have been noted for this gene, but the full-length nature of many is not known. -
Synonyms
PILRB;paired immunoglobin-like type 2 receptor beta;paired immunoglobulin-like type 2 receptor beta;FDFACT1;FDFACT2;activating receptor PILRbeta;cell surface receptor FDFACT;activating receptor PILR-beta;cell surface receptor FDFACT1;cell surface
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PILRB-1720H | Recombinant Human PILRB, GST-tagged | E.coli | Human | GST | 20-188aa | |
| PILRB-1721H | Recombinant Human PILRB protein, GST-tagged | Wheat Germ | Human | GST | 1 a.a. - 227 a.a. |
|
| PILRB-1722H | Recombinant Human PILRB protein, GST-tagged | Wheat Germ | Human | GST | 81 a.a. - 180 a.a. |
|
| PILRB-521H | Recombinant Human PILRB Protein, His-tagged | HEK293 | Human | His | Gln20-Ala189 |
|
| PILRB-636HF | Recombinant Full Length Human PILRB Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 227 amino acids |
|
| PILRB-638HF | Recombinant Full Length Human PILRB Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 227 amino acids |
|
Involved Pathway
PILRB involved in several pathways and played different roles in them. We selected most pathways PILRB participated on our site, such as B Cell Receptor Signaling Pathway,IL-3 Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PILRB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| B Cell Receptor Signaling Pathway | FOS,NFATC2,DUSP6,BANK1,PLEKHA1,IKBKG,VAV3,MAPK3,SOS1,NFKBIB |
| IL-3 Signaling Pathway | GATA1A,SPI1B,KCNIP3B,GATA2A,GATA1,GNB2L1,GATA2,BMX,GSK3AB,BIRC5A |
Protein Function
PILRB has several biochemical functions, for example, MHC class I protein binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PILRB itself. We selected most functions PILRB had, and list some proteins which have the same functions with PILRB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| MHC class I protein binding | ATP5A1,TUBB4B,CD8A,ATP5B,TUBB,TAP1,HLA-E,Pilrb1,BCAP31,VCP |
| protein binding | EXD1,LUM,TRIM13,TSPAN6,IL17RE,DLAT,PCP4,KCNH1,CYP2S1,TGFBI |
Interacting Protein
PILRB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PILRB here. Most of them are supplied by our site. Hope this information will be useful for your research of PILRB.
ABHD16A;menB;katG
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