PIK3R4
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Official Full Name
phosphoinositide-3-kinase, regulatory subunit 4 -
Overview
Phosphoinositide 3-kinase regulatory subunit 4, also known as PI3-kinase regulatory subunit 4 or PI3-kinase p150 subunit or phosphoinositide 3-kinase adaptor protein, or VPS15 is an enzyme that in humans is encoded by the PIK3R4 gene. -
Synonyms
PIK3R4;phosphoinositide-3-kinase, regulatory subunit 4;phosphoinositide 3-kinase regulatory subunit 4;p150;VPS15;PI3-kinase p150 subunit;PI3-kinase regulatory subunit 4;phosphoinositide 3-kinase adaptor protein;phosphatidylinositol 3-kinase-associ
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PIK3R4-1719H | Recombinant Human PIK3R4, His-tagged | E.coli | Human | His | 1-330aa | |
| PIK3R4-12809M | Recombinant Mouse PIK3R4 Protein | Mammalian Cell | Mouse | His |
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| PIK3R4-3183HCL | Recombinant Human PIK3R4 293 Cell Lysate | HEK293 | Human | Non |
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| PIK3R4-1245H | Recombinant Human PIK3R4 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| PIK3R4-6741M | Recombinant Mouse PIK3R4 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| PIK3R4-6741M-B | Recombinant Mouse PIK3R4 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
PIK3R4 involved in several pathways and played different roles in them. We selected most pathways PIK3R4 participated on our site, such as Regulation of autophagy, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3R4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of autophagy | ATG5,IFNPHI1,IFNG1-2,ATG14,IFNA17,ATG4D,IFNA8,PIK3C3,IFNPHI3,GABARAPL1 |
Protein Function
PIK3R4 has several biochemical functions, for example, ATP binding,protein binding,protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3R4 itself. We selected most functions PIK3R4 had, and list some proteins which have the same functions with PIK3R4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein kinase activity | NLK2,CDK9,NAT1,BMPR1AB,CAMK2D2,KSR1,PRPF4BA,PRKCG,GUCY2C,CDKL3 |
| protein serine/threonine kinase activity | ICK,DSTYK,GRK1A,CDC42BPA,MYO3B,SGK2B,MAP3K4,SMG1,SIK2,STK39 |
| ATP binding | IDH3G,DNAJA2,TIMM44,IKBKB,FGFR1A,TSSK6,DDX11,PEBP1,MAPK14A,CHD1L |
| protein binding | FBXO25,GNB2L1,TUBB2A,CASR,HIST2H3C,BCAS2,BPIFA2,ITGA7,COMT,FOSL2 |
Interacting Protein
PIK3R4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3R4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3R4.
ATG14;NRBF2;BECN1
Resources
Research Area
Apoptosis Intracellular KinasesDiabetic Peripheral Neuropathy
Intracellular Kinases in the Akt Pathway
PI 3-Kinases (Phosphoinositide 3-Kinases)
Apical-basal Polarity Effectors
Related Services
Related Products
References
- Ni, Y; Sinnett-Smith, J; et al. PKD1 Mediates Negative Feedback of PI3K/Akt Activation in Response to G Protein-Coupled Receptors. PLOS ONE 8:-(2013).
- Feola, A; Cimini, A; et al. The Inhibition of p85 alpha PI3KSer83 Phosphorylation Prevents Cell Proliferation and Invasion in Prostate Cancer Cells. JOURNAL OF CELLULAR BIOCHEMISTRY 114:2114-2119(2013).
