PIGR
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Official Full Name
polymeric immunoglobulin receptor -
Overview
This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene. -
Synonyms
PIGR;polymeric immunoglobulin receptor;poly-Ig receptor;hepatocellular carcinoma associated protein TB6;hepatocellular carcinoma-associated protein TB6;FLJ22667;MGC125361;MGC125362
Recombinant Proteins
- Human
- Mouse
- Cattle
- Rat
- Chicken
- Zebrafish
- Bovine
- Oryctolagus cuniculus (Rabbit)
- Mus musculus
- HEK293
- Mammalian Cells
- E.coli
- Human Cells
- Insect cells
- Yeast
- His
- Non
- Twin Strep
- Myc&DDK
- His&Fc&Avi
- Fc
Involved Pathway
PIGR involved in several pathways and played different roles in them. We selected most pathways PIGR participated on our site, such as Intestinal i,ne network for IgA production, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIGR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ne network for IgA production | MHC2DEB,HLA-DPB1,HLA-DMB,ICOS,CCL28,Icosl,TNFSF13,BLB2,TNFRSF17,HLA-DRB1 |
| Intestinal i | HLA-DOB,CCL25,IL6,CCL27B,ITGA4,MAP3K14,HLA-DRA,IL15,ITGB7,HLA-DOA |
Protein Function
PIGR has several biochemical functions, for example, polymeric immunoglobulin receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PIGR itself. We selected most functions PIGR had, and list some proteins which have the same functions with PIGR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
PIGR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIGR here. Most of them are supplied by our site. Hope this information will be useful for your research of PIGR.
SGK1;Dynll1;MIS12;cona_canen;CDK6;STK4
Resources
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References
- Armitage, CW; O'Meara, CP; et al. Evaluation of intra- and extra-epithelial secretory IgA in chlamydial infections. IMMUNOLOGY 143:520-530(2014).
- Kaetzel, CS; et al. Cooperativity among secretory IgA, the polymeric immunoglobulin receptor, and the gut microbiota promotes host-microbial mutualism. IMMUNOLOGY LETTERS 162:10-21(2014).
