PIAS2
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Official Full Name
protein inhibitor of activated STAT, 2 -
Overview
This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. -
Synonyms
PIAS2;protein inhibitor of activated STAT, 2;E3 SUMO-protein ligase PIAS2;miz;PIASX ALPHA;PIASX BETA;zinc finger;MIZ type containing 4;ZMIZ4;DAB2-interacting protein;zinc finger, MIZ-type containing 4;msx-interacting zinc finger protein;protei
Recombinant Proteins
- Human
- Chicken
- Rat
- E.coli
- Mammalian Cell
- HEK293
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PIAS2-1703H | Recombinant Human PIAS2, GST-tagged | E.coli | Human | GST | 1-346aa | |
| PIAS2-2335C | Recombinant Chicken PIAS2 | Mammalian Cell | Chicken | His |
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| PIAS2-326H | Recombinant Human PIAS2 Protein, His-tagged | E.coli | Human | His |
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| PIAS2-4442R | Recombinant Rat PIAS2 Protein | Mammalian Cell | Rat | His |
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| PIAS2-3203HCL | Recombinant Human PIAS2 293 Cell Lysate | HEK293 | Human | Non |
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| PIAS2-3204HCL | Recombinant Human PIAS2 293 Cell Lysate | HEK293 | Human | Non |
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| PIAS2-4102R | Recombinant Rat PIAS2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| PIAS2-4102R-B | Recombinant Rat PIAS2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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Involved Pathway
PIAS2 involved in several pathways and played different roles in them. We selected most pathways PIAS2 participated on our site, such as Ubiquitin mediated proteolysis,Jak-STAT signaling pathway,Pathways in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIAS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pathways in cancer | NCOA4,Kitl,PDGFB,F2R,FGF6,MLH1,CBLC,WNT3,GNG7,CYCS |
| Small cell lung cancer | LAMA2,BIRC8,PTEN,ITGA2,RELA,CASP9,TRAF5,TRP53,MAX,BCL2 |
| Jak-STAT signaling pathway | PIK3R2,MPL,AOX3,IL5RA,IFNA17,IFNB1,PRL2,GM2002,AKT2L,AOX2P |
| Ubiquitin mediated proteolysis | MGRN1,UBE2IA,UBE2M,PIAS4B,SKP1,KEAP1B,FBXO2,CUL3A,UBE2E2,UBA2 |
Protein Function
PIAS2 has several biochemical functions, for example, DNA binding,SUMO ligase activity,androgen receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIAS2 itself. We selected most functions PIAS2 had, and list some proteins which have the same functions with PIAS2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | MT1A,ZNF638,KAT7,RBM20,ABP1,MICALL2A,TRIM21,PPARAB,MICAL2,TRIM35 |
| transcription coactivator activity | TAF7,ECD,MAK,SP100,PPARGC1A,SUB1,ESR2,GABPA,GTF2A2,STIL |
| ligase activity | RCHY1,HECW1,TRAIP,TRIML2,SHRPRBCK1R,MDM2,TNFAIP3,BRAP,MARCH1,RNF212 |
| transcription factor binding | DNMT1,MED1,SMARCA4,NKX2-5,TLE1,PPP1R13BB,NFKBIA,TP73,RNF19A,AHR |
| ubiquitin protein ligase binding | CUL5,DBT,MAP1LC3C,STUB1,HM13,CCDC50,Fzd4,KCNH2,UBE2G1B,TMBIM6 |
| androgen receptor binding | KAT5,PRMT2,PRPF6,PIAS1,PKN1,CDK7,NRIP1,FOXH1,DAXX,KDM3A |
| DNA binding | ZFP110,FOXN1,HLX1,NR1D4A,IRX6A,IRX5A,ZMAT2,ADNP2A,BRPF1,ZNF507 |
| protein binding | BCL7A,PITX1,DHX58,SUGT1,MPHOSPH6,ADAM12,MCL1,ZNF136,RNF115,TMA16 |
| SUMO ligase activity | PIAS1,PIAS4 |
Interacting Protein
PIAS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIAS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIAS2.
UBE2I;CCNDBP1;SUMO1;NAV2
PIAS2 Related Signal Pathway
Resources
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References
- Holloway, G; Dang, VT; et al. Rotavirus inhibits IFN-induced STAT nuclear translocation by a mechanism that acts after STAT binding to importin-alpha. JOURNAL OF GENERAL VIROLOGY 95:1723-1733(2014).
- Abkhezr, M; Dryer, SE; et al. Angiotensin II and Canonical Transient Receptor Potential-6 Activation Stimulate Release of a Signal Transducer and Activator of Transcription 3-Activating Factor from Mouse Podocytes. MOLECULAR PHARMACOLOGY 86:150-158(2014).
