PHC2
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Official Full Name
polyhomeotic homolog 2 (Drosophila) -
Overview
In Drosophila melanogaster, the Polycomb group (PcG) of genes are part of a cellular memory system that is responsible for the stable inheritance of gene activity. PcG proteins form a large multimeric, chromatin-associated protein complex. The protein encoded by this gene has homology to the Drosophila PcG protein polyhomeotic (Ph) and is known to heterodimerize with EDR1 and colocalize with BMI1 in interphase nuclei of human cells. The specific function in human cells has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] -
Synonyms
PHC2;polyhomeotic homolog 2 (Drosophila);PH2;EDR2;HPH2;polyhomeotic-like protein 2;polyhomeotic 2;polyhomeotic-like 2;early development regulatory protein 2;early development regulator 2 (homolog of polyhomeotic 2)
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PHC2-1676H | Recombinant Human PHC2, GST-tagged | E.coli | Human | GST | C-term-323aa | |
| PHC2-12711M | Recombinant Mouse PHC2 Protein | Mammalian Cell | Mouse | His |
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| PHC2-1342HCL | Recombinant Human PHC2 cell lysate | Human | Non |
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| PHC2-6679M | Recombinant Mouse PHC2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| PHC2-6679M-B | Recombinant Mouse PHC2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
PHC2 involved in several pathways and played different roles in them. We selected most pathways PHC2 participated on our site, such as Cellular Senescence,Cellular responses to stress,Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with PHC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cellular Senescence | CDKN2C,TERF1,RBB4L,CDKN2B,LMNB1,CDK4,CBX8A,CDKN2D,Txn1,HIST3H2BB |
| Post-translational protein modification | ARSE,SLC35A1,ADAMTSL3,NANP,TMED2,ADAMTS20,ADAMTS3,MUC4,ARSF,GALNT6 |
| SUMO E3 ligases SUMOylate target proteins | RING1,PHC3,NSMCE1,SCMH1,PHC1,RNF2,CBX8,NSMCE2,SMC5,NSMCE4A |
| SUMOylation | NSMCE4A,NSMCE2,SENP5,PHC3,SAE1,SCMH1,SMC6,RING1,NSMCE1,RNF2 |
| Metabolism of proteins | FBXW9,HYOU1,ST3GAL3A,HDGF,ASNA1,KCNA3,TBCC,DOHH,RHBDL1,TIMM50 |
| Cellular responses to stress | SUZ12,UVRAG,ACD,EGLN1B,HIF3A,CEBPB,BAG3,CBX8,WDR45,LC3 |
| Oxidative Stress Induced Senescence | SUZ12B,BMI1B,CBX8B,CBX8,KDM6B,PHC3,MINK1,RING1,SUZ12,EED |
| SUMOylation of DNA damage response and repair proteins | SMC6,CBX8,EID3,NSMCE4A,PHC1,RNF2,PHC3,SCMH1,NSMCE2,NSMCE1 |
Protein Function
PHC2 has several biochemical functions, for example, DNA binding,identical protein binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PHC2 itself. We selected most functions PHC2 had, and list some proteins which have the same functions with PHC2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | DEDD2,RXRAB,ZNF234,HOXC13A,OLIG2,ZFP423,LTF,RYBPA,EGR3,SSH3 |
| zinc ion binding | PAPLN,TRIM3,ZNF205,NBR1,MGRN1A,PCGF5,MMP17,USP13,TNFAIP3,PHRF1 |
| protein binding | EPHA7,DTX3,GRM1,DPYSL5,HOXA1,ARPIN,GLE1,TICAM2,PLCG1,GSTK1 |
| identical protein binding | PAK2,ZNF3,TFRC,MMP9,RUVBL2,PCNA,DYNLT1,SMURF2,SRI,DAPK3 |
Interacting Protein
PHC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PHC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PHC2.
PCGF2;BMI1;SIAH1;CBX8
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References
- Isono, K; Fujimura, Y; et al. Mammalian polyhomeotic homologues Phc2 and Phc1 act in synergy to mediate polycomb repression of Hox genes. MOLECULAR AND CELLULAR BIOLOGY 25:6694-6706(2005).
