PGAM2
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Official Full Name
phosphoglycerate mutase 2 (muscle) -
Overview
Phosphoglycerate mutase (PGAM) catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. The PGAM is a dimeric enzyme containing, in different tissues, different proportions of a slow-migrating muscle (MM) isozyme, a fast-migrating brain (BB) isozyme, and a hybrid form (MB). This gene encodes muscle-specific PGAM subunit. Mutations in this gene cause muscle phosphoglycerate mutase eficiency, also known as glycogen storage disease X. -
Synonyms
PGAM2;phosphoglycerate mutase 2 (muscle);phosphoglycerate mutase 2;PGAM M;BPG dependent PGAM 2;BPG-dependent PGAM 2;GSD10;MGC88743;Muscle specific phosphoglycerate mutase;Muscle-specific phosphoglycerate mutase;OTTHUMP00000207787;PGAM-M;PGAM2_HUMAN;PGAMM;Phosphoglycerate mutase isozyme M
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rat
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- His&T7
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
PGAM2 involved in several pathways and played different roles in them. We selected most pathways PGAM2 participated on our site, such as Glycolysis / Gluconeogenesis,Glycine, serine and threonine metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PGAM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Central carbon metabolism in cancer | SCO2,TP53,TRP53,MAPK1,G6PDX,MAP2K2,PKM2,PIK3CG,AKT2,PFKM |
| Glycolysis / Gluconeogenesis | PGK1,MINPP1A,DLDH,ALDOA,GALM,PKM,HKDC1,G6PCA.2,ALDH1A3,PCK1 |
| Biosynthesis of amino acids | IDH3A,PFKP,CTH,PAH,AADAT,ACY1,pykF,ENO1,GOT2A,TPI1A |
| Glycine, serine and threonine metabolism | AGXTA,CBSB,PGAM1B,DAO1,PSAT1,DLDH,AMT,GRHPRB,AGXT,AOC3 |
| Carbon metabolism | ME3,IDH3G,GPI1,GLUD2,SDHD,PCXB,ACO1,ACSS2,ALDH6A1,OGDHL |
| Metabolic pathways | SGMS1,ATP5A1,ST3GAL4,CYP2A12,DCK,SDS,UGT2B15,PLCB4,MAN2A2,NTPCR |
Protein Function
PGAM2 has several biochemical functions, for example, 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity,bisphosphoglycerate 2-phosphatase activity,bisphosphoglycerate mutase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PGAM2 itself. We selected most functions PGAM2 had, and list some proteins which have the same functions with PGAM2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phosphoglycerate mutase activity | BPGM,PGAM1A,PGAM1,PGAM1B |
| cofactor binding | TYMS,HACL1,BIRC5,ACLYA,UROS,DDO,LMO2,TKT,HIF1AN,DAO |
| 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity | PGAM1A,PGAM1B |
| bisphosphoglycerate mutase activity | PGAM1,BPGM |
| bisphosphoglycerate 2-phosphatase activity | BPGM,C12orf5,PGAM1,TIGARA,TIGARB |
Interacting Protein
PGAM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PGAM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PGAM2.
USP15;NS;GABARAPL1;SH3GLB1
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