PFDN5

  • Official Full Name

    prefoldin subunit 5

  • Overview

    This gene encodes a member of the prefoldin alpha subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. The encoded protein may also repress the transcriptional activity of the proto-oncogene c-Myc. Alternatively spliced transcript variants encoding different isoforms have been described.

  • Synonyms

    PFDN5;prefoldin subunit 5;prefoldin 5;MM 1;PFD5;1190001O17Rik;1700010A06Rik;c myc binding protein;c-myc binding protein MM 1;C-myc-binding protein Mm-1;D15Ertd697e;EIG 1;Eig1;MGC5329;MGC71907;MM1;Myc modulator 1;PFD5_HUMAN;myc modulator-1;c-myc binding protein;MM-1

Recombinant Proteins

  • Human
  • Mouse
  • Rhesus macaque
  • Zebrafish
  • E.coli
  • Mammalian Cells
  • HEK293
  • His
  • Non
  • His&Fc&Avi
  • GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
PFDN5-3608H Recombinant Human PFDN5 protein, His-tagged E.coli Human His 1-154 a.a.
PFDN5-12661M Recombinant Mouse PFDN5 Protein Mammalian Cells Mouse His
PFDN5-28100TH Recombinant Human PFDN5, His-tagged E.coli Human His 154 amino acids
PFDN5-29723TH Recombinant Human PFDN5, His-tagged E.coli Human His Full L. 1-154 a.a.
PFDN5-3382R Recombinant Rhesus monkey PFDN5 Protein, His-tagged Mammalian Cells Rhesus macaque His
PFDN5-359H Recombinant Human PFDN5, His-tagged E.coli Human His Met1-Ala154
PFDN5-6248Z Recombinant Zebrafish PFDN5 Mammalian Cells Zebrafish His
PFDN5-3278HCL Recombinant Human PFDN5 293 Cell Lysate HEK293 Human Non
PFDN5-2580H Recombinant Human PFDN5 Protein, His-tagged E.coli Human His Ala2-Ala154
PFDN5-3200R Recombinant Rhesus Macaque PFDN5 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
PFDN5-3200R-B Recombinant Rhesus Macaque PFDN5 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
PFDN5-6432H Recombinant Human PFDN5 Protein(2-154aa), GST-tagged E.coli Human GST 2-154aa
PFDN5-6652M Recombinant Mouse PFDN5 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
PFDN5-6652M-B Recombinant Mouse PFDN5 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    PFDN5 involved in several pathways and played different roles in them. We selected most pathways PFDN5 participated on our site, such as Chaperonin-mediated protein folding,Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding,Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with PFDN5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Prefoldin mediated transfer of substrate to CCT/TriC CCT7,PFDN4,PFDN6,VBP1,CCT6A,PFDN1,PFDN2
    Protein folding FBXW2,TBCD,PFDN2,PFDN4,FBXW4,PFDN1,VBP1,SERPINA7,CCT6A,FBXW5
    Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding PFDN2,TUBB4B,PFDN4,CCT5,VBP1,CCT4,PFDN1,TUBA3D,CCT2,PFDN6
    Chaperonin-mediated protein folding FBXW9,CCT4,PFDN2,CCT5,PFDN1,PFDN6,FBXL5,KIFC3,CCT6A,NOP56
    Metabolism of proteins TRAPPC6BL,PFDN6,PHC3,CNIH2,DDX11,HDGF,HSCB,EXOSC8,SENP1,UBA2

    Protein Function

    PFDN5 has several biochemical functions, for example, protein binding,transcription corepressor activity,unfolded protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PFDN5 itself. We selected most functions PFDN5 had, and list some proteins which have the same functions with PFDN5. You can find most of the proteins on our site.

    Function Related Protein
    unfolded protein binding TMEM67,AIP,RP2,CRYABB,DNAJA2L,HSP90B1,DNAJB1B,CCT3,CALR,H2-KE2
    protein binding RFC2,USP5,NMB,MALSU1,CCDC137,PNMA5,RSAD2,PTPN22,DAPP1,HMGA1
    transcription corepressor activity WWTR1,LIMD1,TGIF1,PROX1,HEYL,KCNIP3,MSC,TBL1XR1B,HOMEZB,BRD7

    Interacting Protein

    PFDN5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PFDN5 here. Most of them are supplied by our site. Hope this information will be useful for your research of PFDN5.

    vIRF-3;CALCOCO2;GLRX3;PSME3;IKZF3

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