PER2
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Official Full Name
period circadian clock 2 -
Overview
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders. [provided by RefSeq, Jan 2014] -
Synonyms
PER2;period circadian clock 2;FASPS;FASPS1;period circadian protein homolog 2;hPER2;period 2;period homolog 2;period circadian protein 2;circadian clock protein PERIOD 2
Recombinant Proteins
- Mouse
- Human
- Rat
- Chicken
- Zebrafish
- Mammalian Cells
- Wheat Germ
- E.coli
- HEK293
- His
- Non
- T7
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PER2-12636M | Recombinant Mouse PER2 Protein | Mammalian Cells | Mouse | His |
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| PER2-29936TH | Recombinant Human PER2 | Wheat Germ | Human | Non | 100 amino acids |
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| PER2-4378R | Recombinant Rat PER2 Protein | Mammalian Cells | Rat | His |
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| PER2-5835C | Recombinant Chicken PER2 | Mammalian Cells | Chicken | His |
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| PER2-9646Z | Recombinant Zebrafish PER2 | Mammalian Cells | Zebrafish | His |
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| Per2-1924R | Recombinant Rat Per2 protein, His & T7-tagged | E.coli | Rat | His&T7 | Ile179~Pro436 |
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| PER2-4038R | Recombinant Rat PER2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| PER2-4038R-B | Recombinant Rat PER2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| PER2-6637M | Recombinant Mouse PER2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| PER2-6637M-B | Recombinant Mouse PER2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
PER2 involved in several pathways and played different roles in them. We selected most pathways PER2 participated on our site, such as Circadian rhythm,Circadian entrainment,Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with PER2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Circadian rhythm | NR1D1,PRKAB1,RORB,FBXW11,PRKAB2,BTRC,FBXL3,RORA,CLOCK,PRKAG1 |
| Circadian entrainment | GRIN2D,Adcy4,PER1,GNG5,CAMK2A,GNB3,PRKG2,PLCB4,GNG12,GNB1 |
| Herpes simplex infection | MAPK10,TRAF1,MAPK8B,HLA-DOA,NFKBIAB,IFNA8,SRPK1,THOC4,TRAF6,HCFC1 |
| Transcriptional misregulation in cancer | MEF2C,BCL2L1,HIST1H3F,BIRC3,HIST2H3A,CD14,NFKBIZ,SP1,SFPI1,RXRA |
Protein Function
PER2 has several biochemical functions, for example, protein binding,transcription coactivator activity,transcription factor activity, transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PER2 itself. We selected most functions PER2 had, and list some proteins which have the same functions with PER2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, transcription factor binding | TRP63,HIF1A,CRY1,LDB2A,LDB1A,CRY2,TP63,NEUROG1,LDB2B,ASCL1 |
| transcription coactivator activity | BRCA1,ARNT,FUS,MED7,PML,NFATC4,NFKB2,GRIP1,TRIM32,NFE2L3 |
| transcription regulatory region sequence-specific DNA binding | SFPQ,SOX12,KCNA3,NR5A5,GATA1,NKX3-1,NR5A1B,CRY2,NFE2L2,GATA3 |
| protein binding | CUL5,LBP,CWC22,KLHL38,PAK1,GFER,TUBGCP3,MSTN,PKHD1L1,HPX |
| ubiquitin binding | UBXN1,UBAP1,C6orf106,D17WSU92E,AUP1,CRY1,OTUB1B,TOP2A,USP13,UBXN2A |
Interacting Protein
PER2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PER2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PER2.
CSNK1E;TNFRSF14;Csnk1e
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References
- Toda, R; Okano, K; et al. Hypothalamic Expression and Moonlight-Independent Changes of Cry3 and Per4 Implicate Their Roles in Lunar Clock Oscillators of the Lunar-Responsive Goldlined Spinefoot. PLOS ONE 9:-(2014).
- Avitabile, D; Genovese, L; et al. Nucleolar localization and circadian regulation of Per2S, a novel splicing variant of the Period 2 gene. CELLULAR AND MOLECULAR LIFE SCIENCES 71:2547-2559(2014).
