PDK1
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Official Full Name
pyruvate dehydrogenase kinase, isozyme 1 -
Overview
Phosphoinositide-dependent protein kinase 1 (PDK-1) plays a central role in many signal transduction pathways, activating AKT and the PKC isoenzyme p70S6 kinase and RSK. Through its effects on these kinases, PDK-1 is involved in the regulation of wide variety of process, including cell proliferation, differentiation and apoptosis. -
Synonyms
PDK1;pyruvate dehydrogenase kinase, isozyme 1;pyruvate dehydrogenase kinase, isoenzyme 1;mitochondrial pyruvate dehydrogenase, lipoamide, kinase isoenzyme 1
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- Insect Cells
- E.coli
- Mammalian Cells
- Insect cells
- HEK293
- Sf21 Cells
- His
- T7
- Non
- GST
- Flag
- Avi
- Fc
- DDK
- Myc
Involved Pathway
PDK1 involved in several pathways and played different roles in them. We selected most pathways PDK1 participated on our site, such as HIF- signaling pathway,Central carbon metabolism in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Central carbon metabolism in cancer | RAF1,HKDC1,SLC2A2,SLC16A3,HK2,AKT1,C12orf5,NRAS,TP53,PDHA2 |
| HIF- signaling pathway | EIF4E2,ARNT,MAP2K2,INS,BCL2,CUL2,MKNK1,IFNG,LDHA,MKNK2 |
Protein Function
PDK1 has several biochemical functions, for example, ATP binding,protein binding,protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PDK1 itself. We selected most functions PDK1 had, and list some proteins which have the same functions with PDK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | TTC39B,EHMT1,CRYBB3,RPL36AL,TIMM21,MRPS31,MORN2,ZNF193,CCNL1,PRDM1 |
| protein kinase activity | PTK6B,FGFR1B,NEK10,CCL3,TLK1B,AURKC,PRKAA2,NIM1,MAPKAPK2,NTRK2B |
| ATP binding | SMARCA4A,Abca2,STK31,NLRP2,BAZ1B,UBE2W,GTF2F2A,CLCN3,HSPA4B,STK10 |
| pyruvate dehydrogenase (acetyl-transferring) kinase activity | PDK3,PDK4,PDK2 |
Interacting Protein
PDK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PDK1.
SGK3;PDHA1;RPS6KB1;PKN2;EPAS1;XRCC6;VWA8;CELF2;RIMS1;COG4;HMGN1;MYH1;COL4A5;PDK2
PDK1 Related Signal Pathway
Resources
Research Area
Apical-basal Polarity EffectorsKinases Localized to Focal Adhesions
Glycolysis
PI3K Pathway
Related Services
Related Products
References
- Dieni, CA; Storey, KB; et al. Protein kinase C in the wood frog, Rana sylvatica: reassessing the tissue-specific regulation of PKC isozymes during freezing. PEERJ 2:-(2014).
- Hong, HJ; Kang, W; et al. Effects of resveratrol on the insulin signaling pathway of obese mice. JOURNAL OF VETERINARY SCIENCE 15:179-185(2014).
