PDHB
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Official Full Name
pyruvate dehydrogenase (lipoamide) beta -
Overview
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and carbon dioxide, and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 beta subunit. Mutations in this gene are associated with pyruvate dehydrogenase E1-beta deficiency. Alternatively spliced transcript variants have been found for this gene. -
Synonyms
PDHB;pyruvate dehydrogenase (lipoamide) beta;pyruvate dehydrogenase E1 component subunit beta, mitochondrial;pyruvate dehydrogenase, E1 beta polypeptide;PDHBD;PHE1B;PDHE1-B;DKFZp564K0164
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Bacillus subtilis
- Rhesus macaque
- Chicken
- Rat
- Bovine
- E.coli
- Mammalian Cell
- E. coli or Yeast
- Bovine Heart
- E. coli
- HEK293
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
PDHB involved in several pathways and played different roles in them. We selected most pathways PDHB participated on our site, such as Glycolysis / Gluconeogenesis,Citrate cycle (TCA cycle),Pyruvate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDHB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Central carbon metabolism in cancer | NTRK3,C12orf5,HK1,SLC16A3,HIF1A,NRAS,PIK3R1,FGFR3,SLC2A1,KRAS |
| Glycolysis / Gluconeogenesis | ALDH2,PGK2,ACSS2,ACSS1,GPIA,ENO1,FBP1B,GALM,LDHAL6B,ALDH9A1 |
| Citrate cycle (TCA cycle) | DLAT,IDH3A,OGDHA,SDHB,PDHA2,DLD,CS,SDHA,FH1,SDHDB |
| Metabolic pathways | SHMT2,AFMID,BAAT,ALOX8,FDFT1,Ckmm,NDUFB3,PGAM1,GCH2,FASN |
| Pyruvate metabolism | ME2,LDHB,ACACA,DLDH,MDH2,PDPR,PKMA,PCXB,HAGHL,PDK2B |
| HIF- signaling pathway | PDK1,PIK3R5,PIK3R2,HMOX1,TFRC,VHL,IGF1,NPPA,ANGPT1,TEK |
| Carbon metabolism | GPT,GLUD1A,PCCA,PRPS1,PRPS1L1,OGDHA,PGAM1A,PKMB,ENO1A,GOT2A |
Protein Function
PDHB has several biochemical functions, for example, protein binding,contributes_to pyruvate dehydrogenase (NAD+) activity,pyruvate dehydrogenase (acetyl-transferring) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PDHB itself. We selected most functions PDHB had, and list some proteins which have the same functions with PDHB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| pyruvate dehydrogenase (acetyl-transferring) activity | PDHA1A,PDHA2,PDHA1B,PDHA1 |
| contributes_to pyruvate dehydrogenase (NAD+) activity | DLAT,DLD,PDHX |
| pyruvate dehydrogenase activity | PDHA1 |
| protein binding | GTSE1,BATF,ASGR1,CLPX,GNA14,ATP7B,NFKBIA,GRIN2D,BCL2L11,BMP1A |
Interacting Protein
PDHB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDHB here. Most of them are supplied by our site. Hope this information will be useful for your research of PDHB.
DLAT;PDHA1;7242199;GH1;MCC;IKBKE;BRF2;WRAP73;PFDN1;ITGB1;FCER1A;RCC1;ANXA7;AKT1
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