PDGFRL
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Official Full Name
platelet-derived growth factor receptor-like -
Overview
This gene encodes a protein with significant sequence similarity to the ligand binding domain of platelet-derived growth factor receptor beta. Mutations in this gene, or deletion of a chromosomal segment containing this gene, are associated with sporadic hepatocellular carcinomas, colorectal cancers, and non-small cell lung cancers. This suggests this gene product may function as a tumor suppressor. -
Synonyms
PDGFRL;platelet-derived growth factor receptor-like;platelet-derived growth factor receptor-like protein;PRLTS;PDGFR-like protein;PDGF receptor beta-like tumor suppressor;platelet-derived growth factor-beta-like tumor suppressor;PDGRL
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Cynomolgus
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- His
- His&GST
- His&T7
- Non
- His&Fc&Avi
Involved Pathway
PDGFRL involved in several pathways and played different roles in them. We selected most pathways PDGFRL participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PDGFRL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
PDGFRL has several biochemical functions, for example, platelet activating factor receptor activity,platelet-derived growth factor beta-receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PDGFRL itself. We selected most functions PDGFRL had, and list some proteins which have the same functions with PDGFRL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| platelet-derived growth factor beta-receptor activity | PDGFRB |
| platelet activating factor receptor activity | PDGFRB,PTAFR |
Interacting Protein
PDGFRL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDGFRL here. Most of them are supplied by our site. Hope this information will be useful for your research of PDGFRL.
TMEM129;FBP2;CTSV;HRAS;TGFB1;MBP;PFKM;XPA;RANGAP1;MAPK12;PPP2CB;FANCC;MAP2K1;ASPH;BAAT;SPARCL1;SMAD1;MAPKAPK3;SFRP4;PPP3R2
Resources
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References
- Persson, C; Sjoblom, T; et al. Preferential oxidation of the second phosphatase domain of receptor-like PTP-alpha revealed by an antibody against oxidized protein tyrosine phosphatases. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101:1886-1891(2004).
- Kim, SB; Yang, WS; et al. Lipocortin-1 inhibits proliferation of cultured human mesangial cells. NEPHRON 74:39-44(1996).
