PDE6A
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Official Full Name
phosphodiesterase 6A, cGMP-specific, rod, alpha -
Overview
This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa. [provided by RefSeq, Jul 2008] -
Synonyms
PDE6A;phosphodiesterase 6A, cGMP-specific, rod, alpha;PDEA;RP43;CGPR-A;rod cGMP-specific 3,5-cyclic phosphodiesterase subunit alpha;PDE V-B1;GMP-PDE alpha;cGMP phosphodiesterase alpha subunit;rod photoreceptor cGMP phosphodiesterase alpha subunit
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- E.coli
- Sf9 Insect Cell
- Insect Cell
- Mammalian Cell
- HEK293
- His
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PDE6A-1604H | Recombinant Human PDE6A, His-tagged | E.coli | Human | His | 1-90aa | |
| PDE6A-1879H | Recombinant Human PDE6A protein, GST-tagged | E.coli | Human | GST | 1-90 aa | |
| PDE6A-1529H |
Active Recombinant Human PDE6A, GST-tagged
|
Sf9 Insect Cell | Human | GST | 31 aa-end |
|
| PDE6A-1613H |
Active Recombinant Human PDE6A, GST-tagged
|
Sf9 Insect Cell | Human | GST | 31-end |
|
| PDE6A-1613 | Recombinant Human PDE6A protein, GST-tagged | Insect Cell | Human | GST | 31-end |
|
| PDE6A-1650Z | Recombinant Zebrafish PDE6A | Mammalian Cell | Zebrafish | His |
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| PDE6A-30821TH | Recombinant Human PDE6A | Insect Cell | Human | Non | 827 amino acids |
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| PDE6A-3349R | Recombinant Rhesus monkey PDE6A Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| PDE6A-352H | Recombinant Human PDE6A | Mammalian Cell | Human | His |
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| PDE6A-3347HCL | Recombinant Human PDE6A 293 Cell Lysate | HEK293 | Human | Non |
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| PDE6A-3167R | Recombinant Rhesus Macaque PDE6A Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| PDE6A-3167R-B | Recombinant Rhesus Macaque PDE6A Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| PDE6A-3817H | Recombinant Human PDE6A Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| PDE6A-3817H-B | Recombinant Human PDE6A Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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Involved Pathway
PDE6A involved in several pathways and played different roles in them. We selected most pathways PDE6A participated on our site, such as Purine metabolism,Phototransduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE6A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Purine metabolism | APRT,NUDT5,RRM2,ADA,PGM2,CANT1A,PDE7A,DCK,NME1-NME2,POLE3 |
| Phototransduction | GRK7B,CALM2A,RCVRNA,CALM3B,GUCY2E,SAG,RCVRN,GNAT3,GC2,GUCA1A |
Protein Function
PDE6A has several biochemical functions, for example, 3,5-cyclic-GMP phosphodiesterase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE6A itself. We selected most functions PDE6A had, and list some proteins which have the same functions with PDE6A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 3,5-cyclic-GMP phosphodiesterase activity | PDE6C,PDE6G,PDE6H,PDE9A,PDE10A,PDE5A,PDE6B,PDE11A |
| metal ion binding | ZNF80,CRACR2B,PHYHD1,ZSCAN12,NEK7,B3GAT2,ALKBH5,GTPBP6,ME2,IKZF2 |
Interacting Protein
PDE6A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE6A here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE6A.
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