PDCD6
-
Official Full Name
programmed cell death 6 -
Overview
This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant. -
Synonyms
PDCD6;programmed cell death 6;programmed cell death protein 6;ALG 2;apoptosis linked gene 2;PEF1B;apoptosis-linked gene-2;apoptosis-linked gene 2 protein;probable calcium-binding protein ALG-2;ALG-2;MGC9123;FLJ46208;MGC111017;MGC119050
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rhesus macaque
- Cynomolgus
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Fc
- hIgG4
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
PDCD6 involved in several pathways and played different roles in them. We selected most pathways PDCD6 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PDCD6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
PDCD6 has several biochemical functions, for example, binding, bridging,calcium ion binding,calcium-dependent cysteine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PDCD6 itself. We selected most functions PDCD6 had, and list some proteins which have the same functions with PDCD6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | RBP5,FZD8,TNK2,GFI1B,COASY,XAB2,LGI1,MEI4,COPS7B,CD79A |
| binding, bridging | GAS6,TRADD |
| calcium-dependent cysteine-type endopeptidase activity | CAPNS1A,CAPN3,CAPN1A,CAPN11,CAPN2L,PEF1,CAPN3A,CAPN2A,CAPN1B,CAPN2B |
| calcium ion binding | CAPN1A,CDH3,CD69,NCAN,SYT15,PROCA,S100A10,FKBP9,S100T,CRELD2 |
| protein dimerization activity | NPAS2,POLR2J,FAP,SIM1A,HIF3A,GARS,ASCL1B,HER9,HER11,NCOA3 |
| calcium-dependent protein binding | CALM3,KOP,RBM22,MBL1,TNNT3,DMBT1,S100PBP,CALM2,S100A1,MYO1D |
| identical protein binding | ACPP,TP63,ZNHIT6,GLUL,CLPP,ATXN3,Serpina1c,TTR,BAX,CEP170L |
| protein homodimerization activity | UXS1,HNF1B,RASGRP1,TWIST1,PYGB,GDF7,PSPH,GREM2,HPGD,IRAK1 |
| protein anchor | SUN3,MYH9,SUN5,SUN1,NUP153,RAPSN,AKAP6,ALG14,SLC4A1,CIB1 |
Interacting Protein
PDCD6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDCD6 here. Most of them are supplied by our site. Hope this information will be useful for your research of PDCD6.
PEF1;PDCD6IP;PLSCR3
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