PCM1

  • Official Full Name

    pericentriolar material 1

  • Overview

    The protein encoded by this gene is a component of centriolar satellites, which are electron dense granules scattered around centrosomes. Inhibition studies show that this protein is essential for the correct localization of several centrosomal proteins, and for anchoring microtubules to the centrosome. Chromosomal aberrations involving this gene are associated with papillary thyroid carcinomas and a variety of hematological malignancies, including atypical chronic myeloid leukemia and T-cell lymphoma.

  • Synonyms

    PCM1;pericentriolar material 1;pericentriolar material 1 protein;PTC4;hPCM-1;PCM-1;PCM1_HUMAN;OTTHUMP00000224566;OTTHUMP00000224569;OTTHUMP00000224570;pericentriolar material 1, PCM1

Recombinant Proteins

  • Human
  • Mouse
  • Chicken
  • Zebrafish
  • Rat
  • E.coli
  • Mammalian Cells
  • Wheat Germ
  • In Vitro Cell Free System
  • HEK293
  • GST
  • His
  • Non
  • His&T7
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
PCM1-1578H Recombinant Human PCM1, GST-tagged E.coli Human GST 1-254aa
PCM1-3600H Recombinant Human PCM1 protein, His-tagged E.coli Human His 1-254 aa
PCM1-12498M Recombinant Mouse PCM1 Protein Mammalian Cells Mouse His
PCM1-30551TH Recombinant Human PCM1 Wheat Germ Human Non 530 amino acids
PCM1-6100C Recombinant Chicken PCM1 Mammalian Cells Chicken His
PCM1-6543Z Recombinant Zebrafish PCM1 Mammalian Cells Zebrafish His
PCM1-8022H Recombinant Human PCM1 protein, His & T7-tagged E.coli Human His&T7 Pro1913~Ile2024
Pcm1-8023R Recombinant Rat Pcm1 protein, His & T7-tagged E.coli Rat His&T7 Gln15~Val210
PCM1-1312HCL Recombinant Human PCM1 cell lysate Human Non
Pcm1-1927M Recombinant Mouse Pcm1 Protein, His-tagged E.coli Mouse His Asn30-Arg208
PCM1-362HF Recombinant Full Length Human PCM1 Protein In Vitro Cell Free System Human Full L. 530 amino acids
PCM1-4812H Recombinant Human PCM1 Protein (Pro1913-Ile2024), N-GST tagged E.coli Human GST Pro1913-Ile2024
PCM1-6554M Recombinant Mouse PCM1 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
PCM1-6554M-B Recombinant Mouse PCM1 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    PCM1 involved in several pathways and played different roles in them. We selected most pathways PCM1 participated on our site, such as Anchoring of the basal body to the plasma membrane,Assembly of the primary cilium,Cell Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with PCM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell cycle TRP53,SYCP2,SMAD2,RUVBL2,CP110,CEP70,DPF1,TINF2,CSNK1D,GINS4
    Cell Cycle, Mitotic MAPRE1A,CDCA5,ANKLE2,KIF2B,CENPE,CEP290,CKS1B,HIST4H4,ENSAB,NUF2
    Loss of Nlp from mitotic centrosomes PLK4,CEP290,SSNA1,CCP110,CEP63,CEP76,CEP57,TUBG1,CKAP5,HAUS2
    G2/M Transition DCTN3,TUBGCP4,CDK11A,MAPRE1,LIN9,CEP152,NEDD1,MAPRE1A,ACTR1A,CCP110
    Centrosome maturation PLK4,TUBB4B,DCTN1A,TUBG2,CKAP5,DCTN3,DCTN1,CENPJ,NINL,NDE1
    Loss of proteins required for interphase microtubule organizationfrom the centrosome DCTN1A,CEP72,CEP70,HAUS2,CEP164,CENPJ,TSGA14,CLASP1A,CP110,CEP135
    Anchoring of the basal body to the plasma membrane DCTN3,B9D2,DYNC1H1,CLASP1,FGFR1OP,CEP78,CCDC41,MAPRE1B,CCDC123,DCTN2
    Assembly of the primary cilium DYNLL2B,LZTFL1,WDR34,TCTN1,RABL5,IFT122,ATAT1,CEP135,CEP72,CCT4

    Protein Function

    PCM1 has several biochemical functions, for example, identical protein binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PCM1 itself. We selected most functions PCM1 had, and list some proteins which have the same functions with PCM1. You can find most of the proteins on our site.

    Function Related Protein
    identical protein binding ASS1,TRIP10,BAG2,MID1,PARK7,CALCA,GRB2,TPCN1,PTK6,COIL
    protein binding SUCLA2,SLC25A4,PTRF,BAZ1B,ACTN4,EIF3C,IGHMBP2,OAZ1,TBRG4,BIRC5

    Interacting Protein

    PCM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PCM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PCM1.

    BBS4;CCDC53

    Resources

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