PCDH19
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Official Full Name
protocadherin 19 -
Overview
The protein encoded by this gene is a member of the delta-2 protocadherin subclass of the cadherin superfamily. The encoded protein is thought to be a calcium-dependent cell-adhesion protein that is primarily expressed in the brain. Defects in this gene are a cause of epilepsy female-restricted with mental retardation (EFMR). Three transcript variants encoding different isoforms have been found for this gene. -
Synonyms
PCDH19;protocadherin 19;EFMR, epilepsy, female restricted, with mental retardation (Juberg Hellman syndrome);protocadherin-19;EIEE9;KIAA1313;OTTHUMP00000023649;OTTHUMP00000023650;OTTHUMP00000226658;EFMR
Recombinant Proteins
- Mouse
- Human
- Rhesus macaque
- Chicken
- Zebrafish
- Rat
- Mammalian Cells
- Wheat Germ
- E.coli
- HEK293
- His
- GST
- His&Fc&Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PCDH19-12423M | Recombinant Mouse PCDH19 Protein | Mammalian Cells | Mouse | His |
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| PCDH19-15H | Recombinant Human PCDH19 protein, GST-tagged | Wheat Germ | Human | GST | 241-340 a.a. |
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| PCDH19-3320R | Recombinant Rhesus monkey PCDH19 Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| PCDH19-3709C | Recombinant Chicken PCDH19 | Mammalian Cells | Chicken | His |
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| PCDH19-6801Z | Recombinant Zebrafish PCDH19 | Mammalian Cells | Zebrafish | His |
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| Pcdh19-1906R | Recombinant Rat Pcdh19 Protein, His-tagged | E.coli | Rat | His | Lys26-Val192 |
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| PCDH19-3138R | Recombinant Rhesus Macaque PCDH19 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| PCDH19-3138R-B | Recombinant Rhesus Macaque PCDH19 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| PCDH19-6538M | Recombinant Mouse PCDH19 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| PCDH19-6538M-B | Recombinant Mouse PCDH19 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| PCDH19-6564H | Recombinant Human PCDH19 protein, hFc-tagged | HEK293 | Human | Fc | 22-678aa |
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Involved Pathway
PCDH19 involved in several pathways and played different roles in them. We selected most pathways PCDH19 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PCDH19 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
PCDH19 has several biochemical functions, for example, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PCDH19 itself. We selected most functions PCDH19 had, and list some proteins which have the same functions with PCDH19. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | PCDH2AB1,CLGN,ANXA5B,EGFL6,MYL12B,EHD2B,CAPN9,ALOX15B,LOC100686744,PPP3CA |
Interacting Protein
PCDH19 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PCDH19 here. Most of them are supplied by our site. Hope this information will be useful for your research of PCDH19.
Resources
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References
- Ortiz-Medina, H; Emond, MR; et al. ZEBRAFISH CALSYNTENINS MEDIATE HOMOPHILIC ADHESION THROUGH THEIR AMINO-TERMINAL CADHERIN REPEATS. NEUROSCIENCE 286:87-96(2015).
- Duszyc, K; Terczynska, I; et al. Epilepsy and mental retardation restricted to females: X-linked epileptic infantile encephalopathy of unusual inheritance. JOURNAL OF APPLIED GENETICS 56:49-56(2015).
