PCCA

  • Product List
  • Overview
  • Review / Q&A

  • Official Full Name

    propionyl CoA carboxylase, alpha polypeptide

  • Overview

    The protein encoded by this gene is the alpha subunit of the heterodimeric mitochondrial enzyme Propionyl-CoA carboxylase. PCCA encodes the biotin-binding region of this enzyme. Mutations in either PCCA or PCCB (encoding the beta subunit) lead to an enzyme deficiency resulting in propionic acidemia. Multiple transcript variants encoding different isoforms have been found for this gene.

  • Synonyms

    PCCA;propionyl CoA carboxylase, alpha polypeptide;propionyl Coenzyme A carboxylase, alpha polypeptide;propionyl-CoA carboxylase alpha chain, mitochondrial;PCCase subunit alpha;Propanoyl CoA:carbon dioxide ligase subunit alpha;Propionyl CoA carboxylase alpha chain;Propionyl CoA carboxylase alpha chain mitochondrial;Propionyl Coenzyme A Carboxylase Alpha Polypeptide;PCCase alpha subunit;pccA complementation group;propanoyl-CoA:carbon dioxide ligase alpha subunit

Recombinant Proteins

  • Human
  • Rat
  • Zebrafish
  • Mouse
  • E.coli
  • Mammalian Cells
  • HEK293
  • His
  • T7
  • Non
  • Flag
  • Myc
  • Avi
  • Fc
  • GST
  • DDK
Cat.# Product name Source (Host) Species Tag Protein Length Price
PCCA-2785H Recombinant Human PCCA protein, His-tagged E.coli Human His 344 - 703 aa
PCCA-4292R Recombinant Rat PCCA Protein Mammalian Cells Rat His
PCCA-8176H Recombinant Human PCCA protein, His & T7-tagged E.coli Human His&T7 Val580~Glu728
PCCA-842Z Recombinant Zebrafish PCCA Mammalian Cells Zebrafish His
PCCA-3400HCL Recombinant Human PCCA 293 Cell Lysate HEK293 Human Non
PCCA-12H Recombinant Human PCCA Protein, C-MYC/DDK-tagged HEK293 Human Flag&Myc
PCCA-1617H Recombinant Human PCCA Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
PCCA-1617H-B Recombinant Human PCCA Protein Pre-coupled Magnetic Beads HEK293 Human
Pcca-1902M Recombinant Mouse Pcca Protein, His&GST-tagged E.coli Mouse GST&His Asn593-Glu724
PCCA-3954R Recombinant Rat PCCA Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
PCCA-3954R-B Recombinant Rat PCCA Protein Pre-coupled Magnetic Beads HEK293 Rat
PCCA-4806H Recombinant Human PCCA Protein (Val580-Glu728), N-His tagged E.coli Human His Val580-Glu728
Pcca-484M Recombinant Mouse Pcca Protein, MYC/DDK-tagged HEK293 Mouse DDK&Myc
PCCA-502HFL Recombinant Full Length Human PCCA Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.

Involved Pathway

PCCA involved in several pathways and played different roles in them. We selected most pathways PCCA participated on our site, such as Valine, leucine and isoleucine degradation,Glyoxylate and dicarboxylate metabolism,Propanoate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PCCA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Propanoate metabolism SUCLG2,ACACA,HADHAA,ACSS2,ECHDC1,PCCB,LDHC,HIBCH,LDHB,ACSS1
Carbon metabolism GPT,PGAM1A,GPT2L,SDHA,AGXTB,GLDC,PFKMB,TALDO1,HK2,TKTB
Metabolic pathways PNLIPRP3,GNPDA1,MMAB,ALG8,AANAT2,NT5C3B,CS,UGT1A7C,PLA2G5,ARG2
Valine, leucine and isoleucine degradation ACAA1A,ACADM,HADHAA,HMGCS1,AOX3,HADHA,ACADS,ACAA2,ALDH2.2,ACADSB
Glyoxylate and dicarboxylate metabolism CAT,AMT,MCEE,GLULB,SHMT1,ACAT1,GLDC,ANI_1_2390104,GLUL,HOGA1

Protein Function

PCCA has several biochemical functions, for example, ATP binding,biotin binding,biotin carboxylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PCCA itself. We selected most functions PCCA had, and list some proteins which have the same functions with PCCA. You can find most of the proteins on our site.

Function Related Protein
biotin carboxylase activity ACACB,PC,ACACA,PCXA,PCXB,MCCC1
ATP binding FGFR1B,ABCB4,PRKACBB,TAP1,DARS2,MAPK10,RPS6KAL,ACVRL1,CSNK1D,MKI67
propionyl-CoA carboxylase activity PCCB
enzyme binding HNRNPUL1,GSTM4,CBX1,CYB5A,MAPT,PTPN1,HIF1A,TNKS2,MAPK14,PDE4DIP
biotin binding PCXA,PC,HLCS,MCCC1,AVR2,PCXB
metal ion binding ELP3,ZFP30,PRG4B,ZNF563,TRAFD1,ZNF706,IRF2BPL,ZNF397,ZFP579,CYP27C1

Interacting Protein

PCCA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PCCA here. Most of them are supplied by our site. Hope this information will be useful for your research of PCCA.

PARP2;recB;BAG2;US11;IFIT1;PPP2R2B;EBNA-LP;SIRT4

Resources

References

  • Muro, S; Perez, B; et al. Effect of PCCB gene mutations on the heteromeric and homomeric assembly of Propionyl-CoA carboxylase. MOLECULAR GENETICS AND METABOLISM 74:476-483(2001).
  • Stadler, SC; Polanetz, R; et al. Mitochondrial targeting signals and mature peptides of 3-methylcrotonyl-CoA carboxylase. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 334:939-946(2005).

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