PBX1
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Official Full Name
pre-B-cell leukemia homeobox 1 -
Overview
The Pbxs (Pre-B cell leukemia transcription factors) belong to the Three Amino Acid Loop Extension (TALE) family of homeodomain containing protein. Pbx1 has two isoforms, Pbx1a and 1b, that are divergent in sequence at the carboxy terminus, which is a res -
Synonyms
PBX1;pre-B-cell leukemia homeobox 1;pre B cell leukemia transcription factor 1;pre-B-cell leukemia transcription factor 1;homeobox protein PRL;homeobox protein PBX1;MGC126627;DKFZp686B09108
Recombinant Proteins
- Human
- Mouse
- Chicken
- E.coli
- Mammalian Cells
- HEK293
- His
- Non
- His&T7
- Flag
- GST
- Myc&DDK
- His&Fc&Avi
Involved Pathway
PBX1 involved in several pathways and played different roles in them. We selected most pathways PBX1 participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with PBX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transcriptional misregulation in cancer | BMI1,PAX8,PPARG,CCNA1,ARNT2,NFKBIZ,CLSTN2,SIN3A,JMJD1C,MMP3 |
Protein Function
PBX1 has several biochemical functions, for example, DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PBX1 itself. We selected most functions PBX1 had, and list some proteins which have the same functions with PBX1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | CDX4,MITF,NR6A1,SKIL,FOXD1,TBX3,MYF5,CREB3L2,ASCL2,SMAD3 |
| protein binding | HGD,GLYCTK,ADAMTS4,BCKDK,ACMSD,EIF4G1,CD33,DPY30,STX12,LARP1 |
| transcription factor activity, sequence-specific DNA binding | FUBP1,RARGB,NFIL3-5,TAF5L,MSC,NFE2L2,BACH1A,SMAD3A,CRX,ZFP131 |
| transcription factor binding | ARNT,E2F4,TFDP1,IFI203,HEYL,PRKDC,INSIG2,CEBPB,BCL3,HEY2 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | EGR2,HOXC13,BATF,POU4F1,CREB3L2,HOXD13,BCL11B,SMAD4,POU4F3,RELA |
| protein heterodimerization activity | HIST1H47,MCL1A,BDKRB2,HIST1H2BP,DMRT3A,ATF6,TYRP1,ZHX2,BCL2A,ITGA3 |
| DNA binding | EP300,POU3F1,ZFAND6,NKRF,HER12,HOXB1B,ANKRD1,ZFP292,CREB1B,VPS72 |
Interacting Protein
PBX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PBX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PBX1.
FOXC1;HOXB1;MEIS2;MEIS2;Hoxa1;PBX2;MEIS1
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References
- Wang, KP; Zhao, LQ; et al. Differential co-expression analysis of rheumatoid arthritis with microarray data. MOLECULAR MEDICINE REPORTS 10:2421-2426(2014).
- Kiyokawa, N; Iijima, K; et al. Significance of CD66c expression in childhood acute lymphoblastic leukemia. LEUKEMIA RESEARCH 38:42-48(2014).
