PAWR
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Official Full Name
PRKC, apoptosis, WT1, regulator -
Overview
The tumor suppressor WT1 represses and activates transcription. The protein encoded by this gene is a WT1-interacting protein that itself functions as a transcriptional repressor. It contains a putative leucine zipper domain which interacts with the zinc finger DNA binding domain of WT1. This protein is specifically upregulated during apoptosis of prostate cells. -
Synonyms
PAWR;PRKC, apoptosis, WT1, regulator;PRKC apoptosis WT1 regulator protein;par 4;PAR4;WT1-interacting protein;transcriptional repressor PAR4;prostate apoptosis response 4 protein;prostate apoptosis response protein 4;prostate apoptosis response pr
Recombinant Proteins
- Mouse
- Zebrafish
- Human
- Rat
- Mammalian Cells
- HEK293
- Wheat Germ
- E.coli
- His
- DDK
- Myc
- Non
- GST
- Avi
- Fc
- Flag
Involved Pathway
PAWR involved in several pathways and played different roles in them. We selected most pathways PAWR participated on our site, such as Ceramide signaling pathway,Coregulation of Androgen receptor activity,IL-4 signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAWR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Coregulation of Androgen receptor activity | PA2G4,TGFB1I1,KDM1A,PIAS3,PATZ1,SVIL,ZMIZ1,TCF4,NRIP1,CMTM2 |
| Ceramide signaling pathway | DERL3,EGF,CRADD,CTSD |
| IL-4 signaling Pathway | SPI1B,DOK2,HMGA1-RS1,ADRBK2,IL4R.1 |
Protein Function
PAWR has several biochemical functions, for example, actin binding,enzyme binding,leucine zipper domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PAWR itself. We selected most functions PAWR had, and list some proteins which have the same functions with PAWR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ZBTB25,RGS14,FRAG1,GPSM1,ACPL2,CASP9,PAG1,CEP70,MYOZ1,PDCD5 |
| leucine zipper domain binding | ATF4,KCNA3,CRX,DAPK3,NRL,ERC1,DDIT3,PMF1,AATF,MKL1 |
| protein kinase C binding | PARD3,TOP2A,PRKCB,ADD3,FLNA,PLEK,LDB3,NELL2,FEZ1,UGT1A7 |
| protein phosphatase 1 binding | PHACTR4,Fert2,TCTEX1D4,PHACTR3B,PHACTR3,PHACTR4B,KCNQ1,SH3RF2,FER,PHACTR1 |
| enzyme binding | UBE2L3,CAD,GOLPH3,PEX7,PLCB1,PTPLAD2,HIST1H2AI,KDM4C,MTA1,SIRT1 |
| actin binding | WASLA,RUSC1,TLN2A,EZR,RP2,MED28,TWF1B,ACTN3,MYH11A,PACRG |
| transcription corepressor activity | ALX1,TOB1,SF1,RUNX1T1,TLE4,ZHX1,ZHX3,ENO1,YWHAB,KCNIP3 |
Interacting Protein
PAWR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAWR here. Most of them are supplied by our site. Hope this information will be useful for your research of PAWR.
HSPA5;Spsb2;SPSB1;Spsb4;SPSB4;SPSB2;Spsb1;Kif23
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