Parp2

  • Official Full Name

    poly (ADP-ribose) polymerase 2

  • Overview

    This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found.

  • Synonyms

    PARP2;poly (ADP-ribose) polymerase 2;ADP ribosyltransferase (NAD+;poly(ADP ribose) polymerase) like 2 , ADPRTL2, poly (ADP ribose) polymerase family, member 2;poly [ADP-ribose] polymerase 2;ADP ribosyltransferase like 2;ADPRT 2;ADPRT-2;ADPRT2;ADPRTL 2;ADPRTL 3;ADPRTL2;ADPRTL3;hPARP 2;hPARP-2;hPARP2;NAD(+) ADP ribosyltransferase 2;NAD(+) ADP-ribosyltransferase 2;pADPRT 2;pADPRT-2;pADPRT2;PARP 2;PARP-2;PARP2_HUMAN;Poly (ADP ribose) polymerase family member 2;Poly (ADP ribosyl) transferase like 2;Poly [ADP ribose] synthetase 2;Poly(ADP ribose) synthetase;Poly[ADP-ribose] synthase 2;OTTHUMP00000231900;OTTHUMP00000231902;OTTHUMP00000231904;poly(ADP-ribose) synthetase;poly[ADP-ribose] synthetase 2;poly (ADP-ribosyl) transferase-like 2;poly (ADP-ribose) polymerase family, member 2;ADP-ribosyltransferase (NAD+;poly(ADP-ribose) polymerase)-like 2

Recombinant Proteins

  • Mouse
  • Human
  • Rhesus macaque
  • Zebrafish
  • Sf21 Insect Cell
  • Mammalian Cell
  • Insect Cell
  • Sf9 Insect Cell
  • E.coli
  • Insect cell
  • HEK293
  • Insect cells
  • His
  • GST
  • Non
  • His&Fc&Avi
  • N-GST&C-His
Cat.# Product name Source (Host) Species Tag Protein Length Price
Parp2-453M Active Recombinant Mouse Parp2, His-tagged Sf21 Insect Cell Mouse His
PARP2-12373M Recombinant Mouse PARP2 Protein Mammalian Cell Mouse His
PARP2-157H Recombinant Human PARP2 Protein, GST-tagged Insect Cell Human GST 2-583
PARP2-3308R Recombinant Rhesus monkey PARP2 Protein, His-tagged Mammalian Cell Rhesus macaque His
PARP2-433H Recombinant Human Poly (ADP-ribose) Polymerase 2, GST-tagged Sf9 Insect Cell Human GST 2-583 a.a.
Parp2-613M Recombinant Mouse Poly (ADP-ribose) Polymerase Family, Member 2 Sf9 Insect Cell Mouse Non Full L.
Parp2-641M Recombinant Mouse Parp2, His-tagged Sf21 Insect Cell Mouse His
PARP2-7559H Recombinant Human PARP2, His-tagged E.coli Human His 233-583aa
PARP2-8014Z Recombinant Zebrafish PARP2 Mammalian Cell Zebrafish His
Kit-1799 PARP2 Chemiluminescent Assay Kit Non
Kit-1800 PARP2 Colorimetric Assay Kit Non
Kit-1801 PARP2 Homogeneous Assay Kit Non
PARP2-006H Recombinant Human PARP2 Protein, GST-tagged Insect cell Human GST 2-583
PARP2-3126R Recombinant Rhesus Macaque PARP2 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
PARP2-3126R-B Recombinant Rhesus Macaque PARP2 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
PARP2-3858H Recombinant Human PARP2 Protein (Ser223-Trp583), N-His tagged E.coli Human His Ser223-Trp583
PARP2-4533H Recombinant Human PARP2 protein, His-tagged E.coli Human His 233-583aa
PARP2-6506M Recombinant Mouse PARP2 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
PARP2-6506M-B Recombinant Mouse PARP2 Protein Pre-coupled Magnetic Beads HEK293 Mouse
PARP2-6754H Recombinant Human PARP2 protein, GST&His-tagged Insect cells Human N-GST&C-His 1-583aa

    Involved Pathway

    Parp2 involved in several pathways and played different roles in them. We selected most pathways Parp2 participated on our site, such as Base Excision Repair,DNA Damage Recognition in GG-NER,DNA Double-Strand Break Repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with Parp2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    DNA Damage Recognition in GG-NER COPS7B,NFRKB,COPS4,COPS5,MCRS1,ACTR5,CETN2,COPS8,YY1A,INO80B
    Dual Incision in GG-NER DDB1,DDB2,CHD1L
    Global Genome Nucleotide Excision Repair (GG-NER) ACTL6A,COPS5,YY1,COPS7A,COPS4,MCRS1,DDB2,GPS1,INO80C,COPS3
    DNA Repair COPS6,KIAA0146,WRN,PPP4R2B,ALKBH2,POLD3,RTEL1,COPS5,PAXIP1,KDM4A
    Base excision repair POLE4,POLL,mutY,PARP1,xthA,NTHL1,PARP3,POLD1,POLD3,NEIL2
    DNA Double-Strand Break Repair DNA2,RAD9,UBE2V2,RAD51AP1,CLSPN,BAZ1B,TDP2,EME1,POLD3,GEN1
    Formation of Incision Complex in GG-NER RNF111,PIAS3,DDB1,CHD1L,USP45,DDB2,CETN2

    Protein Function

    Parp2 has several biochemical functions, for example, DNA binding,NAD+ ADP-ribosyltransferase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Parp2 itself. We selected most functions Parp2 had, and list some proteins which have the same functions with Parp2. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding YBX2,SIX6A,DDX41,TFEC,ZBTB7B,TRIM33,TCEANC2,SIX3A,ZNF177,ATOH7
    protein binding TACC1,SOCS1,TCF7,RINT1,CENPI,MYLK2,BMI1,OAS1,HACL1,MYO10
    NAD+ ADP-ribosyltransferase activity GIG2G,PARP11,GIG2D,CHAT2,TNKS,GIG2Q,GIG2I,GIG2K,PARP4,GIG2H

    Interacting Protein

    Parp2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Parp2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Parp2.

    FKBP3;STAC;FAM168B;VPS37C;nad+;mgc:39545;NDUFA4;SYNJ2;DFFB;MYO1D;RTN3;IFNA16;PCCA;HMGN2;HIST1H1E;CD58;PTMS

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