PARP16
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Official Full Name
poly (ADP-ribose) polymerase family, member 16 -
Overview
Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by theaddition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) toglu/asp residues on the substrate protein, and also polymerizes ADP-ribose to form long/branched chainpolymers. PARP inhibitors are being developed for use in a number of pathologies including cancer, diabetes,stroke and cardiovascular disease. -
Synonyms
PARP16;poly (ADP-ribose) polymerase family, member 16;C15orf30, chromosome 15 open reading frame 30;poly [ADP-ribose] polymerase 16;FLJ20509;FLJ25281;pART15;C15orf30;Chromosome 15 open reading frame 30;EC 2.4.2.30;PAR16_HUMAN;PARP 16;PARP-16;Poly (ADP ribose) polymerase family member 16;Poly [ADP ribose] polymerase 16
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rat
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- His
- GST
- DDK
- Myc
- Non
- Avi
- Fc
- Flag
Involved Pathway
PARP16 involved in several pathways and played different roles in them. We selected most pathways PARP16 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PARP16 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
PARP16 has several biochemical functions, for example, NAD+ ADP-ribosyltransferase activity,kinase binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PARP16 itself. We selected most functions PARP16 had, and list some proteins which have the same functions with PARP16. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| kinase binding | HSP90AB1,JAKMIP2,BTG1,STRADA,TRIP6,CDC37,GFAP,PRKCD,TNFAIP3,SLC2A1 |
| protein binding | CCT2,HPCAL1,CCDC170,SRRT,LDLRAD1,ATF7,KLK8,SRA1,UTF1,PTPN11A |
| protein serine/threonine kinase activator activity | MAP2K1,FAM20A,MAP2K2,CDK5R1,SPRY2,STRADA,STK4,CALM3,CAB39,ALS2 |
| NAD+ ADP-ribosyltransferase activity | GIG2I,PARP14,GIG2F,PARP1,PARP15,GIG2G,ART5,PARP12,GIG2H,PARP6 |
Interacting Protein
PARP16 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PARP16 here. Most of them are supplied by our site. Hope this information will be useful for your research of PARP16.
FLJ13057;Cyr61;Setd5;MLKL;DOT1L;MRPL1;PCIF1;ZNF644;KLC4
Resources
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References
- Qiu, W; Lam, R; et al. Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 70:2740-2753(2014).
- Bayraktar, S; Barrera, AMG; et al. USP-11 as a Predictive and Prognostic Factor Following Neoadjuvant Therapy in Women With Breast Cancer. CANCER JOURNAL 19:10-17(2013).
