PADI1
-
Official Full Name
peptidyl arginine deiminase, type I -
Overview
This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type I enzyme is involved in the late stages of epidermal differentiation, where it deiminates filaggrin and keratin K1, which maintains hydration of the stratum corneum, and hence the cutaneous barrier function. This enzyme may also play a role in hair follicle formation. This gene exists in a cluster with four other paralogous genes. -
Synonyms
PADI1;peptidyl arginine deiminase, type I;protein-arginine deiminase type-1;hPAD colony 10;HPAD10;PAD1;PDI;PDI1;peptidylarginine deiminase type I;protein arginine deiminase type 1;hPAD-colony 10;peptidylarginine deiminase I;protein-arginine de
Recombinant Proteins
- Human
- Rat
- Mouse
- Insect Cell
- Sf9 Insect Cell
- Mammalian Cell
- E.coli
- HEK293
- Yeast
- Mammalian cells
- HEK293T
- GST
- His
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
PADI1 involved in several pathways and played different roles in them. We selected most pathways PADI1 participated on our site, such as Chromatin modifying enzymes,Chromatin organization,protein citrullination, which may be useful for your reference. Also, other proteins which involved in the same pathway with PADI1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chromatin organization | RBBP7,SUZ12,PHF15,JMJD6,SUDS3,KAT7A,ING4,SUZ12A,KIAA1267,SMARCB1A |
| protein citrullination | PADI4,PADI6,PADI3,PADI2 |
| Chromatin modifying enzymes | DR1,MBD3B,MBIP,KDM4D,ARID5B,MORF4L1,SETD3,PADI4,ARID4A,SMYD3 |
Protein Function
PADI1 has several biochemical functions, for example, calcium ion binding,protein-arginine deiminase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PADI1 itself. We selected most functions PADI1 had, and list some proteins which have the same functions with PADI1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | GUCA1E,CALB2,NINL,EHD2,THBS3,CABP4,GAS6,PCDHB6,BMP1,MMP11 |
| protein-arginine deiminase activity | PADI4,PADI6,PADI3,PADI2 |
Interacting Protein
PADI1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PADI1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PADI1.
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