P4HTM
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Official Full Name
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) -
Overview
The product of this gene belongs to the family of prolyl 4-hydroxylases. This protein is a prolyl hydroxylase that may be involved in the degradation of hypoxia-inducible transcription factors under normoxia. It plays a role in adaptation to hypoxia and may be related to cellular oxygen sensing. Alternatively spliced variants encoding different isoforms have been identified. -
Synonyms
P4HTM;prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum);transmembrane prolyl 4-hydroxylase;EGLN4;FLJ20262;HIFPH4;hypoxia inducible factor prolyl 4 hydroxylase;P4H TM;PH 4;PH4;PHD4;Prolyl hydroxlase domain containing 4;HIF prolyl hydroxylase PH4;HIF-PH4;HIF-prolyl hydroxylase 4;HPH-4;Hypoxia inducible factor prolyl hydroxylase;Hypoxia-inducible factor prolyl hydroxylase 4;P4H with transmembrane domain;P4H-TM;P4HTM_HUMAN;Proline 4 hydroxylase;Prolyl 4 hydroxylase transmembrane (endoplasmic reticulum);OTTHUMP00000082685;OTTHUMP00000082686;proline 4-hydroxylase;Prolyl hydroxlase domain-containing 4;hypoxia;PH-4
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| P4HTM-1500H | Recombinant Human P4HTM, GST-tagged | E.coli | Human | GST | 218-563aa | |
| P4HTM-3370H | Recombinant Human P4HTM protein, His-tagged | E.coli | Human | His | 218-563 aa | |
| P4HTM-3479HCL | Recombinant Human P4HTM 293 Cell Lysate | HEK293 | Human | Non |
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| P4HTM-4865H | Recombinant Human P4HTM protein, His-SUMO-tagged | E.coli | Human | His&SUMO | 82-563aa |
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Involved Pathway
P4HTM involved in several pathways and played different roles in them. We selected most pathways P4HTM participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with P4HTM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
P4HTM has several biochemical functions, for example, L-ascorbic acid binding,iron ion binding,oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors. Some of the functions are cooperated with other proteins, some of the functions could acted by P4HTM itself. We selected most functions P4HTM had, and list some proteins which have the same functions with P4HTM. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors | KDM5B,KDM5C,HIF1AN,PHF8,C14orf169,KDM5BA,EGLN1,TYW5,JHDM1D,ALKBH5 |
| L-ascorbic acid binding | OGFOD1,PLOD1A,PAM,PLOD3,FAM125B,P4HA1A,P4HA1,LEPREL1,P4HA1B,TMLHE |
| iron ion binding | XDH,P4HA1,MTRR,PLOD2,BBOX1,ALOX15,CYP2AA2,CYP4F22,HBAE3,FAXDC2 |
Interacting Protein
P4HTM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with P4HTM here. Most of them are supplied by our site. Hope this information will be useful for your research of P4HTM.
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