OTC
-
Official Full Name
ornithine carbamoyltransferase -
Overview
This nuclear gene encodes a mitochondrial matrix enzyme. Missense, nonsense, and frameshift mutations in this enzyme lead to ornithine transcarbamylase deficiency, which causes hyperammonemia. Since the gene for this enzyme maps close to that for Duchenne muscular dystrophy, it may play a role in that disease also. -
Synonyms
OTC;ornithine carbamoyltransferase;ornithine carbamoyltransferase, mitochondrial;OTCase;ornithine transcarbamylase;OCTD;MGC129967;MGC129968;MGC138856
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- E.coli
- Mammalian Cells
- HEK293
- Insect Cells
- His
- His&T7
- His&Fc&Avi
- His&SUMO
- Flag
- Myc&DDK
Involved Pathway
OTC involved in several pathways and played different roles in them. We selected most pathways OTC participated on our site, such as Arginine biosynthesis,Metabolic pathways,Biosynthesis of amino acids, which may be useful for your reference. Also, other proteins which involved in the same pathway with OTC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | MAOB,CYP21A2,DNMT3B,ST6GALNAC1,IDI2,ASPA,SEPHS2,UPB1,UOX,PYGB |
| Biosynthesis of amino acids | TKTL2,PGAM2,PSPH,ALDOC,SHMT1,PKMB,PRPS1A,ENO2,SDS,ENO3 |
| Arginine biosynthesis | NOS2,GLUL,GLS2,NOS2A,ACY1,GLUD1,GPT2L,CPS1,ASL,ybaS |
Protein Function
OTC has several biochemical functions, for example, amino acid binding,ornithine carbamoyltransferase activity,phosphate ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by OTC itself. We selected most functions OTC had, and list some proteins which have the same functions with OTC. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| amino acid binding | PAH,AARS2,GCHFR,TPH1B,DPYS,DDAH2,SHMT2,TAT,KARS,TDO2 |
| phospholipid binding | APOA2,SNCA,BPIFC,HIP1RB,NSFL1C,BIN2,SPTBN2,SHC1,F10,PLA2G15 |
| phosphate ion binding | ADSSL1,PNP,CHST14,RELA,RPH3A,ADSS,GNG12,SH2B3,G6PC,MTHFD2 |
Interacting Protein
OTC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with OTC here. Most of them are supplied by our site. Hope this information will be useful for your research of OTC.
Resources
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References
- Mendling, W; et al. Guideline: Vulvovaginal Candidosis (AWMF 015/072), S2k (excluding chronic mucocutaneous candidosis). MYCOSES 58:1-15(2015).
- Wongtangprasert, T; Natakuathung, W; et al. Production of a monoclonal antibody against oxytetracycline and its application for oxytetracycline residue detection in shrimp. JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B 15:165-172(2014).
