ORC2
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Official Full Name
origin recognition complex, subunit 2 -
Overview
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. This protein forms a core complex with ORC3, -4, and -5. It also interacts with CDC45 and MCM10, which are proteins known to be important for the initiation of DNA replication. This protein has been demonstrated to specifically associate with the origin of replication of Epstein-Barr virus in human cells, and is thought to be required for DNA replication from viral origin of replication. Alternatively spliced transcript variants have been found, one of which is a nonsense-mediated mRNA decay candidate. -
Synonyms
ORC2L;origin recognition complex subunit 2;OTTHUMP00000163672;origin recognition complex, subunit 2-like;origin recognition complex protein 2 homolog;origin recognition complex, subunit 2 homolog;ORC2;origin recognition complex, subunit 2
Recombinant Proteins
- Chicken
- Rat
- Human
- Mouse
- Mammalian Cells
- HEK293
- His
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ORC2-1655C | Recombinant Chicken ORC2 | Mammalian Cells | Chicken | His |
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| ORC2-4200R | Recombinant Rat ORC2 Protein | Mammalian Cells | Rat | His |
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| ORC2-289H | Recombinant Human ORC2 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| ORC2-2904H | Recombinant Human ORC2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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| ORC2-3862R | Recombinant Rat ORC2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| ORC2-3862R-B | Recombinant Rat ORC2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| Orc2-4599M | Recombinant Mouse Orc2 Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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Involved Pathway
ORC2 involved in several pathways and played different roles in them. We selected most pathways ORC2 participated on our site, such as Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with ORC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell cycle | CDC20,CUL1B,PHF8,CEP152,UBE2V2,TFDP1,CDC6,PIANP,NCAPD2,YWHAQ |
Protein Function
ORC2 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by ORC2 itself. We selected most functions ORC2 had, and list some proteins which have the same functions with ORC2. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
ORC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ORC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ORC2.
Resources
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References
- Sahashi, R; Matsuda, R; et al. Functional analysis of Drosophila DNA polymerase epsilon p58 subunit. AMERICAN JOURNAL OF CANCER RESEARCH 3:478-489(2013).
- Hubner, K; Phi-van, L; et al. In Vivo Binding of Orc2 to a Region of the Chicken Lysozyme GAS41 Origin Containing Multiple Sp1-Binding Sites. DNA AND CELL BIOLOGY 31:180-186(2012).
