OPHN1
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Official Full Name
oligophrenin 1 -
Overview
This gene encodes a Rho-GTPase-activating protein that promotes GTP hydrolysis of Rho subfamily members. Rho proteins are important mediators of intracellular signal transduction, which affects cell migration and cell morphogenesis. Mutations in this gene are responsible for OPHN1-related X-linked mental retardation with cerebellar hypoplasia and distinctive facial dysmorhphism. -
Synonyms
OPHN1;oligophrenin 1;mental retardation, X linked 60 , MRX60;oligophrenin-1;ARHGAP41;OPN1;OTTHUMP00000023451;mental retardation, X-linked 60;oligophrenin-1, Rho-GTPase activating protein;MRX60
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Mouse
- Zebrafish
- E.coli
- Mammalian Cells
- HEK293
- His
- His&T7
- Myc&DDK
- His&Fc&Avi
Involved Pathway
OPHN1 involved in several pathways and played different roles in them. We selected most pathways OPHN1 participated on our site, such as Rho GTPase cycle,Signal Transduction,Signaling by Rho GTPases, which may be useful for your reference. Also, other proteins which involved in the same pathway with OPHN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling by Rho GTPases | TAX1BP3,ARHGAP9,WIPF3,STARD8,ARHGEF18A,ARHGAP6,ARHGAP18,RHPN2,ROPN1,FGD4 |
| Signal Transduction | TAS2R7,PYY,RGS1,GPR55A,OPN4A,NOTUM,FGFBP2,TNKS,KREMEN2,PTHRP2 |
| Rho GTPase cycle | FGD4,ARHGAP10,GDI2,ARHGAP25,ABR,CHN2,ARHGAP4,ARHGAP36,FAM13B1,STARD13 |
Protein Function
OPHN1 has several biochemical functions, for example, GTPase activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by OPHN1 itself. We selected most functions OPHN1 had, and list some proteins which have the same functions with OPHN1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase activator activity | RGS14,ARRB1,RASA3,ARHGAP33,SRGAP2,RALGAPA1,TBC1D16,TBC1D9B,CHN2,RGS3 |
Interacting Protein
OPHN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with OPHN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of OPHN1.
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