OPA3
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Official Full Name
optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) -
Overview
The mouse ortholog of this protein co-purifies with the mitochondrial inner membrane. Mutations in this gene have been shown to result in 3-methylglutaconic aciduria type III and autosomal dominant optic atrophy and cataract. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
OPA3;optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia);optic atrophy 3 protein;FLJ22187;MGA3;FLJ25932;Iraqi Jewish optic atrophy plus (3 methylglutaconicaciduria type 3);MGC75494;OPA 3;OPA3 protein;Optic atrophy 3 (Iraqi Jewish optic atrophy plus);Optic atrophy 3;Optic atrophy 3 (Iraqi-Jewish optic atrophy plus)
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Zebrafish
- Rat
- E.coli
- Mammalian Cells
- HEK293
- His
- His&T7
- Non
- His&Fc&Avi
- Flag
Involved Pathway
OPA3 involved in several pathways and played different roles in them. We selected most pathways OPA3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with OPA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
OPA3 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by OPA3 itself. We selected most functions OPA3 had, and list some proteins which have the same functions with OPA3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
OPA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with OPA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of OPA3.
SUV39H1;KDM1A;PRMT6
Resources
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References
- Sergouniotis, PI; Perveen, R; et al. Clinical and molecular genetic findings in autosomal dominant OPA3-related optic neuropathy. NEUROGENETICS 16:69-75(2015).
- Yahalom, G; Anikster, Y; et al. Costeff syndrome: clinical features and natural history. JOURNAL OF NEUROLOGY 261:2275-2282(2014).
