OGN
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Official Full Name
osteoglycin -
Overview
Osteoglycin(also Mimecan), encoded by the OGN gene is a human protein. This gene encodes a protein which induces ectopic bone formation in conjunction with transforming growth factor beta. This protein is a small proteoglycan which contains tandem leucine-rich repeats (LRR). The gene expresses three transcript variants. -
Synonyms
OGN;osteoglycin;OG;OIF;SLRR3A;DKFZp586P2421;osteoglycin (osteoinductive factor);mimecan;mimecan proteoglycan;Osteoinductive factor;OTTHUMP00000021650;OTTHUMP00000021651;OTTHUMP00000063691;corneal keratan sulfate proteoglycan
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Chicken
- Mouse
- Rat
- E.coli
- Mammalian Cell
- HEK293
- Yeast
- HEK293T
- Mammalian cells
- His
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
OGN involved in several pathways and played different roles in them. We selected most pathways OGN participated on our site, such as Defective B4GALT1 causes B4GALT1-CDG (CDG-2d),Defective CHST6 causes MCDC1,Defective ST3GAL3 causes MCT12 and EIEE15, which may be useful for your reference. Also, other proteins which involved in the same pathway with OGN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Defective ST3GAL3 causes MCT12 and EIEE15 | KERA,FMOD,PRELP,ACAN |
| Keratan sulfate biosynthesis | B3GNT1,KERA,B3GNT2A,SLC35D2,FMODA,B3GNT2,PRELP,ST3GAL3A,OMD,B3GNT3 |
| Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) | PRELP,KERA,FMOD,ACAN |
| Diseases of glycosylation | FMOD,PRELP,ACAN,KERA |
| Disease | STX1B,RLBP1,CPSF4,CCDC167,NA,TTR,JAG1,PSTPIP2,RBP1,CYP11A1 |
| Diseases associated with glycosaminoglycan metabolism | FMOD,ACAN,PRELP,KERA |
| Defective CHST6 causes MCDC1 | ACAN,KERA,PRELP,FMOD |
| Glycosaminoglycan metabolism | B4GALT7,KERA,B3GAT2,SLC26A2,PRELP,KIAA1199,HAS1,HPSE,GPC1A,ST3GAL3A |
Protein Function
OGN has several biochemical functions, for example, NOT Roundabout binding,growth factor activity,heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by OGN itself. We selected most functions OGN had, and list some proteins which have the same functions with OGN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CABLES1,FAM59A,KIFC3,LONRF3,RXRB,FUT11,MCM7,RNF41,KRT33B,RCC2 |
| heparin binding | LIPC,PTPRF,FGFBP1,HDGF,NRP2,GREM2,CCDC80,ELANE,PTN,THBS3 |
| growth factor activity | FGF11,CSF2,OSM,AGT,IL8L2,FGF4,INHBC,BMP7,FGF14,THBS4 |
| NOT Roundabout binding | FMODA,FMOD,EPYC |
Interacting Protein
OGN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with OGN here. Most of them are supplied by our site. Hope this information will be useful for your research of OGN.
ABL1;SRC;CRK
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References
- Heppner, JM; Zaucke, F; et al. Extracellular matrix disruption is an early event in the pathogenesis of skeletal disease in mucopolysaccharidosis I. MOLECULAR GENETICS AND METABOLISM 114:146-155(2015).
- Chun, YS; Park, Y; et al. O-GlcNAcylation Promotes Non-Amyloidogenic Processing of Amyloid-beta Protein Precursor via Inhibition of Endocytosis from the Plasma Membrane. JOURNAL OF ALZHEIMERS DISEASE 44:261-275(2015).
