OGG1
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Official Full Name
8-oxoguanine DNA glycosylase -
Overview
This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. -
Synonyms
OGG1;8-oxoguanine DNA glycosylase;N-glycosylase/DNA lyase;8 hydroxyguanine DNA glycosylase;HMMH;HOGG1;MUTM;OGG1 type 1d;OGG1 type 1e;OGG1 type 1g;OGG1 type 1h;OGH1;AP lyase;OGG1 type 1f;8-hydroxyguanine DNA glycosylase;DNA-apurinic or apyri
Recombinant Proteins
- Human
- Mouse
- Yeast
- Rhesus macaque
- Rat
- Chicken
- Zebrafish
- E.coli
- Mammalian Cell
- Yeast
- HEK293
- GST
- His
- Non
- His&GST
- His&Fc&Avi
- His&SUMO
Involved Pathway
OGG1 involved in several pathways and played different roles in them. We selected most pathways OGG1 participated on our site, such as Base excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with OGG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Base excision repair | POLD3,NTHL1,POLD2,PARP4,SMUG1,nth,UNGA,PARP2,APEX2,POLE4 |
Protein Function
OGG1 has several biochemical functions, for example, 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity,DNA N-glycosylase activity,damaged DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by OGG1 itself. We selected most functions OGG1 had, and list some proteins which have the same functions with OGG1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| oxidized purine DNA binding | RPS3 |
| damaged DNA binding | MPG,RAD23AB,TP53BP1,UNG,POLH,GTF2H3,FANCG,RAD1,TP63,DCLRE1C |
| DNA N-glycosylase activity | SMUG1,TDG,NTHL1,NEIL3,NEIL1 |
| protein binding | VRK1,NBR1,HSP90AA1,SFPQ,ZBTB44,SLC6A18,MAD2L1BP,RAB17,Ntng2,NR1H2 |
| endonuclease activity | DIS3,ANG3,NTHL1,DROSHA,PPP1R8,RNASEL3,RNASEKA,MRE11A,G3BP1,ZRANB3 |
| oxidized purine nucleobase lesion DNA N-glycosylase activity | RPS3 |
Interacting Protein
OGG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with OGG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of OGG1.
XPC;31652240;Ogg1;SNRPF;CHGB;Hspd1
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References
- Sattarova, EA; Sinitsyna, OI; et al. Age-dependent guanine oxidation in DNA of different brain regions of Wistar rats and prematurely aging OXYS rats. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1830:3542-3552(2013).
- Young, SC; Chang, LW; et al. DNA Damage Induced by trans, trans-2,4-Decadienal (tt-DDE), a Component of Cooking Oil Fume, in Human Bronchial Epithelial Cells. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS 51:315-321(2010).
