NUDT15
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Official Full Name
nudix (nucleoside diphosphate linked moiety X)-type motif 15 -
Synonyms
NUDT15;nudix (nucleoside diphosphate linked moiety X)-type motif 15;23063;ENSG00000136159;MTH2;RP11-90M2.1;13q14.2;FLJ10956, MGC104352;probable 8-oxo-dGTP diphosphatase NUDT15;probable 8-oxo-dGTP diphosphatase NUDT15;A730068G11Rik;mutT homolog 2;nudix motif 15;nudix-type motif 15;8-oxo-dGTPase NUDT15;7,8-dihydro-8-oxoguanine-triphosphatase NUDT15;nucleoside diphosphate-linked moiety X motif 15;probable 7,8-dihydro-8-oxoguanine triphosphatase NUDT15;EC 3.6.1.55
Recombinant Proteins
- Mouse
- Human
- Zebrafish
- Mammalian Cells
- E.coli
- HEK293
- Nicotiana Benthamiana
- His
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
NUDT15 involved in several pathways and played different roles in them. We selected most pathways NUDT15 participated on our site, such as Metabolism,Metabolism of nucleotides,Phosphate bond hydrolysis by NUDT proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with NUDT15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phosphate bond hydrolysis by NUDT proteins | NUDT16,NUDT1,NUDT18,NUDT5 |
| Metabolism of nucleotides | DTYMK,TYMP,AK8,PNP5B,NUDT1,GRX2,AK7A,DPYD,TM9SF1,AK7 |
| Metabolism | DHODH,PPM1L,MED26,CYP2K22,GLS2B,CYP2V1,CETP,ARSH,SLC25A32,MED7 |
Protein Function
NUDT15 has several biochemical functions, for example, 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity,8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NUDT15 itself. We selected most functions NUDT15 had, and list some proteins which have the same functions with NUDT15. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity | NUDT1 |
| 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity | NUDT19,DOM3Z,NUDT1 |
| metal ion binding | ZFP35,CALUB,SDHDB,HBAA1,CYP1A,TPH1A,GUCA1G,Itgam&Itgb2,SIAH1A,CYP2C39 |
Interacting Protein
NUDT15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NUDT15 here. Most of them are supplied by our site. Hope this information will be useful for your research of NUDT15.
SRD5A3
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References
- Teruya, R; Ikejiri, AT; et al. Expression of oxidative stress and antioxidant defense genes in the kidney of inbred mice after intestinal ischemia and reperfusion. ACTA CIRURGICA BRASILEIRA 28:848-855(2013).
- Yang, SK; Hong, M; et al. A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia. NATURE GENETICS 46:1017-+(2014).
