NTHL1
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Official Full Name
nth endonuclease III-like 1 (E. coli) -
Overview
The protein encoded by this gene is a DNA N-glycosylase of the endonuclease III family. Like a similar protein in E. coli, the encoded protein has DNA glycosylase activity on DNA substrates containing oxidized pyrimidine residues and has apurinic/apyrimidinic lyase activity. -
Synonyms
NTHL1;nth endonuclease III-like 1 (E. coli);nth (E.coli endonuclease III) like 1;endonuclease III-like protein 1;NTH1;OCTS3;Endonuclease III like protein 1;NTH 1;NTH endonuclease III Like 1;NTHL 1;NTHL1_HUMAN;OCTS 3;OTTHUMP00000158939
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NTHL1-107H | Recombinant Human NTHL1 Protein, His-tagged | E.coli | Human | His |
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| NTHL1-20H | Recombinant Human NTHL1 protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| NTHL1-2488H | Recombinant Human Nth Endonuclease III-Like 1 (E. coli), His-tagged | E.coli | Human | His | 1-312aa |
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| NTHL1-3545C | Recombinant Chicken NTHL1 | Mammalian Cell | Chicken | His |
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| NTHL1-1982H | Recombinant Human NTHL1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| Nthl1-4519M | Recombinant Mouse Nthl1 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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Involved Pathway
NTHL1 involved in several pathways and played different roles in them. We selected most pathways NTHL1 participated on our site, such as Base excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with NTHL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Base excision repair | POLL,MUTYH,MPG,POLE4,xthA,LIG1,HMGB1A,POLD2,TDG.1,POLE2 |
Protein Function
NTHL1 has several biochemical functions, for example, 4 iron, 4 sulfur cluster binding,DNA N-glycosylase activity,DNA-(apurinic or apyrimidinic site) lyase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NTHL1 itself. We selected most functions NTHL1 had, and list some proteins which have the same functions with NTHL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 4 iron, 4 sulfur cluster binding | TYW1B,REV3L,IREB2,NUBPL,NDUFS1,POLD1,NDUFS8A,NDUFS7,ISCUB,NFU1 |
| double-stranded DNA binding | SETMAR,MTERFD3,RAD51L3,FBXO18,FEV,MTERF3,TRP63,HMGB2,IFI16,DMC1 |
| protein binding | SLC9A1,MEOX1,CAV2,MAMSTR,DNM2,C4orf33,TACC3,SSBP3,GSE1,SMUG1 |
| endonuclease activity | G3BP1,CENPT,RNASE6,RNASEL2,SETMAR,EAR14,DROSHA,ZC3H12A,EAR1,CL2 |
| oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity | SMUG1 |
| metal ion binding | ARSE,ZFP354C,ZNF576,ZFAND5A,ZFP422,MGAT4B,IDI2,ANKZF1,ZNF563,ZBTB7B |
| DNA N-glycosylase activity | NEIL3,NEIL1,TDG,OGG1,SMUG1 |
| DNA-(apurinic or apyrimidinic site) lyase activity | APEX1,HMGA2,NEIL3,NEIL2,ALKBH1,APLF,HMGA1B,HMGA1,RPS3,HMGA1-RS1 |
Interacting Protein
NTHL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NTHL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NTHL1.
GAPDHS;MYH7;RBL1;NUDT1;RNMTL1;RPL10;Rpl35;CAMKK1;Gspt1
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References
- De Summa, S; Pinto, R; et al. Expression of base excision repair key factors and miR17 in familial and sporadic breast cancer. CELL DEATH & DISEASE 5:-(2014).
- Corral, R; Lewinger, JP; et al. Genetic Variation in the Base Excision Repair Pathway, Environmental Risk Factors, and Colorectal Adenoma Risk. PLOS ONE 8:-(2013).
