NSD1

  • Official Full Name

    nuclear receptor binding SET domain protein 1

  • Overview

    This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene.

  • Synonyms

    NSD1;nuclear receptor binding SET domain protein 1;Sotos syndrome , STO;histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific;ARA267;FLJ22263;KMT3B;H3-K36-HMTase;H4-K20-HMTase;lysine N-methyltransferase 3B;NR-binding SET dom

Recombinant Proteins

  • Human
  • E.coli
  • Insect Cell
  • His
  • GST
  • Non
Cat.# Product name Source (Host) Species Tag Protein Length Price
NSD1-2813H Recombinant Human NSD1 protein, His-tagged E.coli Human His 341-630 aa
NSD1-03H Active Recombinant Human NSD1 protein, GST-tagged E.coli Human GST 1852-2082aa
NSD1-143H Recombinant Human NSD1 Protein, His-tagged Insect Cell Human His 1538-2696
NSD1-82H Recombinant Human NSD1, GST-tagged E.coli Human GST 1849-2094 a.a.
Kit-1787 NSD1 Chemiluminescent Assay Kit Non
NSD1-002H Recombinant Human NSD1 Protein, GST-tagged E.coli Human GST 1700-1986
NSD1-035H Recombinant Human NSD1 Protein, GST-tagged E.coli Human GST 1700-1986

    Involved Pathway

    NSD1 involved in several pathways and played different roles in them. We selected most pathways NSD1 participated on our site, such as Lysine degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with NSD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Lysine degradation AGXT2L2,ALDH9A1A.1,TMLHE,WBP7,SUV39H2,BBOX1,ALDH2.2,PLOD1A,COLGALT2,HADHAA

    Protein Function

    NSD1 has several biochemical functions, for example, RNA polymerase II core promoter sequence-specific DNA binding,androgen receptor binding,chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NSD1 itself. We selected most functions NSD1 had, and list some proteins which have the same functions with NSD1. You can find most of the proteins on our site.

    Function Related Protein
    transcription cofactor activity PTPN14,MAX,NFE2L1,RFXANK,PHF21A,SLC26A3,IRF3,ELK4,ZNF865,SUPT20H
    thyroid hormone receptor binding TAF11,MED12,MED1,ZNHIT3,MED4,HMGN3,GAS2L1,MED13,NCOA3,MED30
    retinoic acid receptor binding ASXL1,HMGA1-RS1,AASS,LRIF1,ACTN4,PRMT2,MED1,PRAMEF10,PRAMEF6,PRAME
    transcription corepressor activity ID4,E2F6,BCL11A,NANOG,CBFA2T3,SETD8,IRF2BP2,SKOR1,MTA1,THRB
    retinoid X receptor binding HMGA1-RS1,RARB,PPARG,NR1H4,RARG,NCOR1,HMGA1,NR0B2,FUS,NCOA1
    histone methyltransferase activity (H4-K20 specific) WHSC1,SUV420H1,SUV420H2
    histone methyltransferase activity (H3-K36 specific) SMYD2,SMYD2B,SMYD2A,SETD2,ASH1L,SETD3,SETMAR
    estrogen receptor binding CTNNB1,PHB2,DYX1C1,NCOA1,NKX3,MMS19,PADI2,TAF10,CCDC62,XBP1
    RNA polymerase II core promoter sequence-specific DNA binding SOX11,TP53,TRP53,ZFPM1,SOX3,GATA1,SP3,HNF4A,TCF7L2,PAX6

    Interacting Protein

    NSD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NSD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NSD1.

    zntA;glgX

    Resources

    References

    • Cui, JJ; McTigue, M; et al. Discovery of a Novel Class of Exquisitely Selective Mesenchymal-Epithelial Transition Factor (c-MET) Protein Kinase Inhibitors and Identification of the Clinical Candidate 2-(4-(1-(Quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol (PF-04217903) for the Treatment of Cancer. JOURNAL OF MEDICINAL CHEMISTRY 55:8091-8109(2012).
    • Rhee, JM; Iannaccone, PM; et al. Mapping mouse hemangioblast maturation from headfold stages. DEVELOPMENTAL BIOLOGY 365:1-13(2012).

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