NRXN1
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Official Full Name
neurexin 1 -
Synonyms
NRXN1;neurexin 1;neurexin-1-beta;Hs.22998;KIAA0578;neurexin I;neurexin I-beta;neurexin I-alpha;neurexin-1-alpha;PTHSL2;SCZD17;FLJ35941;DKFZp313P2036
Recombinant Proteins
- Human
- Rat
- Mouse
- Chicken
- Mammalian Cells
- HEK293
- Fc
- His
- Non
- Avi
- Flag
- DDK
- Myc
- Twin Strep
Involved Pathway
NRXN1 involved in several pathways and played different roles in them. We selected most pathways NRXN1 participated on our site, such as Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with NRXN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell adhesion molecules (CAMs) | VCAN,ITGB2,CLDNE,JAM2,NCAM1,CNTNAP2,CLDN11,ITGAV,CLDN17,CLDN20 |
Protein Function
NRXN1 has several biochemical functions, for example, acetylcholine receptor binding,calcium channel regulator activity,calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NRXN1 itself. We selected most functions NRXN1 had, and list some proteins which have the same functions with NRXN1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | ZSCAN21,TCN2,ZBTB8OS,ITGB2,SDHD,ADHFE1,CA15B,TIPARP,CYBRD1,TRIM108 |
| transmembrane signaling receptor activity | LYVE1,P2RX6,LGR4,NRXN2,TLR7,GPR113,GLP1R,OR6K3,TLR9,SLC22A17 |
| neuroligin family protein binding | NRXN3,NRXN2,DLG4 |
| receptor binding | FGF1B,NRG3,MTSS1,YES1,TESPA1,F2,Fgf15,CADM2,HAO1,F7 |
| acetylcholine receptor binding | KCNS1,RAPSN,RIC3,APP,JAK2,DLG4,RER1,UBXN2A |
| receptor activity | IGF2R,XPR1,CD244,NLGN3B,CD160,TLR3,CSF2RB,RET,CADM1,GFRA1A |
| calcium ion binding | CIB2,NELL2A,RYR3,SYT5,PCDHGA6,ANXA1B,PCDH2AB12,CCDC167,SYT9B,RHOT1 |
| calcium channel regulator activity | GRM3,TMEM110,GRM7,NRXN2,SGK2A,SGK3,PRKCB,CACNA2D3,STIM2,PRKG1 |
| calcium-dependent protein binding | CLEC4M,CALM2,SEC31A,VPS37B,ANXA3,SELP,SLC9A1,ANXA7,ANXA2,ANXA4 |
Interacting Protein
NRXN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NRXN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NRXN1.
Resources
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References
- Giannone, G; Mondin, M; et al. Neurexin-1 beta Binding to Neuroligin-1 Triggers the Preferential Recruitment of PSD-95 versus Gephyrin through Tyrosine Phosphorylation of Neuroligin-1. CELL REPORTS 3:1996-2007(2013).
- Savvaki, M; Panagiotaropoulos, T; et al. Impairment of learning and memory in TAG-1 deficient mice associated with shorter CNS internodes and disrupted juxtaparanodes. MOLECULAR AND CELLULAR NEUROSCIENCE 39:478-490(2008).
