NR0B2
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Official Full Name
nuclear receptor subfamily 0, group B, member 2 -
Overview
The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. -
Synonyms
NR0B2;nuclear receptor subfamily 0, group B, member 2;nuclear receptor subfamily 0 group B member 2;SHP;nuclear receptor SHP;small heterodimer partner;orphan nuclear receptor SHP;SHP1;FLJ17090
Recombinant Proteins
- Chicken
- Rat
- Human
- Mammalian Cell
- E.coli
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NR0B2-2582C | Recombinant Chicken NR0B2 | Mammalian Cell | Chicken | His |
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| NR0B2-4061R | Recombinant Rat NR0B2 Protein | Mammalian Cell | Rat | His |
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| NR0B2-638H | Recombinant Human NR0B2 Protein, His-tagged | E.coli | Human | His |
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| NR0B2-3722HCL | Recombinant Human NR0B2 293 Cell Lysate | HEK293 | Human | Non |
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| NR0B2-3606H | Recombinant Human NR0B2 Protein (Met1-Arg257), His tagged | E.coli | Human | His | Met1-Arg257 |
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| NR0B2-3720R | Recombinant Rat NR0B2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| NR0B2-3720R-B | Recombinant Rat NR0B2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| NR0B2-473H | Recombinant Human NR0B2 Protein, His-tagged | E.coli | Human | His | Met1~Arg257 |
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| Nr0b2-474R | Recombinant Rat Nr0b2 Protein, His-tagged | E.coli | Rat | His | Met1~Arg260 |
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| NR0B2-6066H | Recombinant Human NR0B2 Protein, GST-tagged | Wheat Germ | Human | GST |
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| NR0B2-6690HF | Recombinant Full Length Human NR0B2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 257 amino acids |
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Involved Pathway
NR0B2 involved in several pathways and played different roles in them. We selected most pathways NR0B2 participated on our site, such as Bile secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with NR0B2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Bile secretion | NR1H4,NCEH1,SLC22A8,LDLR,SLCO1B2,ABCG2,BAAT,PRKACA,SLC10A1,ABCC3 |
Protein Function
NR0B2 has several biochemical functions, for example, DNA binding,peroxisome proliferator activated receptor binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NR0B2 itself. We selected most functions NR0B2 had, and list some proteins which have the same functions with NR0B2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | DAXX,S100A10,CAMK2G,ATPIF1B,NR6A1B,MID1,SPPL2B,UGT1A6A,DMRTB1,IRF3 |
| protein domain specific binding | TUBB,GNAI3,CBX3,HIST1H4B,ZBTB16,TRIM11,DDX6,MYO1D,TWIST2,CSNK2B |
| transcription factor binding | HES6,PPP1R13BA,PRKDC,IGHMBP2,NAB1,BCOR,UBE2I,GPX3,ESR1,SOX10 |
| protein complex binding | ATP6V0D1,BRK1,PROS1,CALY,GNB1,NFYB,C8B,CEBPA,PRKACA,UQCRFS1 |
| DNA binding | TFPT,TBPL2,PURG,MYCL1,HOXA3A,KDM2AA,PHC2A,ARHGEF38,HOXC13A,DLX1A |
| transcription corepressor activity | RBFOX2,SOD3,ZNF593,NSD1,HDAC7,NOC2L,SSX4,TLE2,ZBTB32,TSG101 |
| steroid hormone receptor activity | PPARDB,NR1D1,PPARAB,NR1D2,ESR1,THRA,ESR2,NR5A1B,NR3C2,RORAA |
| retinoid X receptor binding | NRIP1,HMGA1,NCOA1,VDR,NR1H2,PPARG,NCOR1,HMGA1-RS1,FUS,RARG |
| thyroid hormone receptor binding | GTF2B,MED12,NCOA3,TAF7,TRIP6,THRAP3,NUP62,HMGN3,ZNHIT3,OASL |
Interacting Protein
NR0B2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NR0B2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NR0B2.
SIRT1;TP53;MDM2;PLSCR1;ESRRG;Traf6;ZMYND10;FN1;HNRNPA1
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References
- Fujii, S; Nishikawa-Torikai, S; et al. Nr0b1 is a negative regulator of Zscan4c in mouse embryonic stem cells. SCIENTIFIC REPORTS 5:-(2015).
- Nam, YS; Kim, Y; et al. Small Heterodimer Partner Blocks Cardiac Hypertrophy by Interfering With GATA6 Signaling. CIRCULATION RESEARCH 115:493-+(2014).
