NPSR1
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Official Full Name
neuropeptide S receptor 1 -
Overview
This gene is a member of the G protein-coupled receptor 1 family and encodes a plasma membrane protein. Increased expression of this gene in ciliated cells of the respiratory epithelium and in bronchial smooth muscle cells is associated with asthma. Mutations in this gene have also been associated with this disease. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008] -
Synonyms
NPSR1;neuropeptide S receptor 1;GPRA;NPSR;VRR1;ASRT2;PGR14;GPR154;neuropeptide S receptor;G protein-coupled receptor 154;G-protein coupled receptor 154;G-protein coupled receptor PGR14;G protein-coupled receptor for asthma susceptibility;G-protein coupled receptor for asthma susceptibility
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Macaca mulatta
- Mus musculus
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Non
- Avi
- Fc
Involved Pathway
NPSR1 involved in several pathways and played different roles in them. We selected most pathways NPSR1 participated on our site, such as Class A/1 (Rhodopsin-like receptors),G alpha (q) signalling events,G alpha (s) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with NPSR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Class A/1 (Rhodopsin-like receptors) | CXCL11.8,OXGR1,APLN,KISS1,RGS1,CCR6,GPR37L1,CNR1,OPN4B,GPR31 |
| Signal Transduction | PTHRP2,ARHGAP9,ADM,CCL35.2,PTH2,ARHGAP23,OR4D2,PTPRK,GPR4,CDC37 |
| G alpha (s) signalling events | CRHR2,ADM2A,INSL3,CALCRL,ADORA2A,CRH,VIP,PTHLHA,RAMP1,ADORA2B |
| G alpha (q) signalling events | ANXA1,EDNRAB,QRFPR,KALRNB,OPN4B,NMBA,EDN2,RGS19,KALRN,NTS |
| Gastrin-CREB signalling pathway via PKC and MAPK | NPFFR2,ANXA1,FFAR3,PROK2,OPN4,FPR-RS3,PMCH,NMU,QRFP,RGS19 |
| GPCR ligand binding | PTHLH,RLN2,GPR120,CX3CR1,OPN1MW,FPR-RS6,GNB5B,EDN2,HCAR1-2,SST1.1 |
| GPCR downstream signaling | ADORA2A,OPN4B,NPB,CASR,GNA13B,CNR2,GPBAR1,PIK3R6,PROK2,INSL5 |
| Peptide ligand-binding receptors | TAC2,GPR37L1,SSTR5,HEBP1,NMS,NMB,PENKA,PNOCB,PROKR1,PROKR1A |
Protein Function
NPSR1 has several biochemical functions, for example, neuropeptide receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NPSR1 itself. We selected most functions NPSR1 had, and list some proteins which have the same functions with NPSR1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| neuropeptide receptor activity | SORCS2,MCHR1,NPFFR1,PRLHR,KISS1R,SORCS1,NMUR1,HCRTR1,NPFFR2.1,SORCS3 |
Interacting Protein
NPSR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NPSR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NPSR1.
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