NMU
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Official Full Name
Neuromedin U -
Overview
Neuromedin U (NmU) is a vertebrate peptide which stimulates uterine smooth muscle contraction and causes selective vasoconstriction. Like most other active peptides, it is proteolytically processed from a larger precursor protein. The mature peptides are 8 (NmU-8) to 25 (NmU-25) residues long and C-terminally amidated. The sequence of the C-terminal extremity of NmU is extremely well conserved across species. -
Synonyms
NmU;Neuromedin U;Neuromedin U 25;NmU 25
Recombinant Proteins
- Human
- Rat
- Chicken
- HEK293
- Mammalian Cells
- E.coli
- Wheat Germ
- In Vitro Cell Free System
- His
- His&GST
- His&T7
- Non
- His&Fc&Avi
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NMU-34H | Recombinant Human NMU, His-tagged | HEK293 | Human | His | 1-174 a.a. |
|
| NMU-4010R | Recombinant Rat NMU Protein | Mammalian Cells | Rat | His |
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| NMU-5253C | Recombinant Chicken NMU | Mammalian Cells | Chicken | His |
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| NMU-5254C | Recombinant Chicken NMU | Mammalian Cells | Chicken | His |
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| NMU-5751H | Recombinant Human NMU protein, His & GST-tagged | E.coli | Human | His&GST | Ala35~Ile158 |
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| Nmu-5752R | Recombinant Rat Nmu protein, His & T7-tagged | E.coli | Rat | His&T7 | Cys38~Ile174 |
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| NMU-741H | Recombinant Human NMU | Mammalian Cells | Human | His |
|
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| NMU-3781HCL | Recombinant Human NMU 293 Cell Lysate | HEK293 | Human | Non |
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| NMU-3645H | Recombinant Human NMU Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| NMU-3645H-B | Recombinant Human NMU Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| NMU-3669R | Recombinant Rat NMU Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| NMU-3669R-B | Recombinant Rat NMU Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| NMU-3940H | Recombinant Human NMU Protein (Ala35-Ile174), N-GST tagged | E.coli | Human | GST | Ala35-Ile174 |
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| NMU-5946H | Recombinant Human NMU Protein, GST-tagged | Wheat Germ | Human | GST |
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| NMU-6604HF | Recombinant Full Length Human NMU Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 36-174 amino acids |
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Involved Pathway
NMU involved in several pathways and played different roles in them. We selected most pathways NMU participated on our site, such as Class A/1 (Rhodopsin-like receptors),G alpha (i) signalling events,G alpha (q) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with NMU were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| G alpha (q) signalling events | GRP,TRPC6A,OPN4,FPR-RS6,GCGB,GPR17,RGS19,PROKR1,OPN4.1,NPSR1 |
| G alpha (i) signalling events | S1PR5B,RGS7,PNOCB,RGS6,ADORA1,GAL,OPN1SW,S1PR1,POMCB,RGS19 |
| Class A/1 (Rhodopsin-like receptors) | GPR18,TAC3,CYSLTR1,EDNRAB,PMCH,CXCL13,ADRA1D,RXFP2,OXGR1A.2,CCR7 |
| Gastrin-CREB signalling pathway via PKC and MAPK | NTS,GRP,PRKCHB,ABHD12,FPR-RS3,EDN3,UTS2,OPN4.1,NMBB,ANXA1B |
| GPCR downstream signaling | ECT2,OR4D2,OPN4A,GNA13,OPN1SW,GPR68,ARHGEF25,CGA,PLEKHG2,ADRA2A |
| GPCR ligand binding | SST,CNR2,FPR-RS3,APLN,HCRT,EDNRB,CCL35.2,NTS,GPR31,OPN4A |
| Signal Transduction | RGS11,RGS4,ARHGAP40,WIF1,CXCL11.8,SKILB,PRKCHB,CCK,PTPRUB,OPN4.1 |
| Peptide ligand-binding receptors | CXCL11.8,ACKR4,HCRT,PRLH,CCBP2,SSTR1,CCL19A.2,NPFF,GPR37L1,CXCR7B |
Protein Function
NMU has several biochemical functions, for example, neuromedin U receptor binding,protein binding,receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NMU itself. We selected most functions NMU had, and list some proteins which have the same functions with NMU. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | PSMA5,GUCY1A3,OPA1,PACS1,TTBK2,HCLS1,C10orf28,SH3GLB1,GOLGA7,EIF4EA |
| receptor binding | ACOT8,LGI1,PECR,PVRL1,GDNF,IZUMO1,DVL3,ICAM3,MAP7,GCG |
Interacting Protein
NMU has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NMU here. Most of them are supplied by our site. Hope this information will be useful for your research of NMU.
KRTAP5-9;NOTCH2NL;TNS2
Resources
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References
- Rani, S; Corcoran, C; et al. Neuromedin U: A Candidate Biomarker and Therapeutic Target to Predict and Overcome Resistance to HER-Tyrosine Kinase Inhibitors. CANCER RESEARCH 74:3821-3833(2014).
- Zhang, YM; Jiang, DS; et al. Neuromedin U Type 1 Receptor Stimulation of A-type K+ Current Requires the beta gamma Subunits of G(o) Protein, Protein Kinase A, and Extracellular Signal-regulated Kinase 1/2 (ERK1/2) in Sensory Neurons. JOURNAL OF BIOLOGICAL CHEMISTRY 287:18562-18572(2012).
