NMT1
-
Official Full Name
N-myristoyltransferase 1 -
Overview
Myristate, a rare 14-carbon saturated fatty acid, is cotranslationally attached by an amide linkage to the N-terminal glycine residue of cellular and viral proteins with diverse functions. N-myristoyltransferase (NMT; EC 2.3.1.97) catalyzes the transfer of myristate from CoA to proteins. N-myristoylation appears to be irreversible and is required for full expression of the biologic activities of several N-myristoylated proteins, including the alpha subunit of the signal-transducing guanine nucleotide-binding protein (G protein) GO (GNAO1; MIM 139311) (Duronio et al., 1992 -
Synonyms
NMT1;N-myristoyltransferase 1;glycylpeptide N-tetradecanoyltransferase 1;alternative;short form NMT S;long form;NMT L;myristoyl CoA:protein N myristoyltransferase;NMT;NMT 1;long form, NMT-L;alternative, short form NMT-S;type I N-myristoyltrans
Recombinant Proteins
- Mouse
- Rat
- Human
- Mammalian Cell
- HEK293
- Mammalian cells
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
- GST
Involved Pathway
NMT1 involved in several pathways and played different roles in them. We selected most pathways NMT1 participated on our site, such as Activation, myristolyation of BID and translocation to mitochondria,Apoptosis,Disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with NMT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HIV Life Cycle | VPS37A,CDK9,PDCD6IP,PSIP1,ELL,CHMP4C,PSTPIP2,CHMP4B,NMT2,SSRP1 |
| Intrinsic Pathway for Apoptosis | DIABLOB,DIABLO,Gzmg,GZMC,BAXB,GZME,DIABLOA,GZMF |
| Inactivation, recovery and regulation of the phototransduction cascade | GNB5A,PPEF1,METAP2A,METAP1,RGS9BP,SAGB,GUCA1E,RLN1,CNGA1,NMT1A |
| Apoptosis | TNFRSF10A,IL1B2,TICAM1,SPNA2,PRKAR2AB,PLEC,TP53,DSP,IRF1B,MAP3K14 |
| Disease | RNF43,FMOD,CDK8,FGFR1OP2,DPF1,TNKS,LRRFIP1,SUPT5H,KPNA4,TLR10 |
| Infectious disease | PDCD6IP,AP1M2,IPO5,TAF1L,LTF,PPIAL4A,KPNA5,KPNA4,NMT2,EEF2 |
| HIV Infection | SSRP1,AP1B1,APOBEC3G,TCEB3,CHMP4C,NPM1,CHMP4B,PSIP1,AP1G1,AP1S1 |
| Activation, myristolyation of BID and translocation to mitochondria | GZMF,Gzmg,GZME,GZMC |
Protein Function
NMT1 has several biochemical functions, for example, glycylpeptide N-tetradecanoyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NMT1 itself. We selected most functions NMT1 had, and list some proteins which have the same functions with NMT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glycylpeptide N-tetradecanoyltransferase activity | NMT1A,NMT2,NMT1B |
Interacting Protein
NMT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NMT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NMT1.
nef;TP53;CAPN2;ssrna_ug;NOP56;VIM;Eif3a;Rpl35;Rrbp1;Ccdc77;Wdr61
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References
- Rampoldi, F; Sandhoff, R; et al. A new, robust, and nonradioactive approach for exploring N-myristoylation. JOURNAL OF LIPID RESEARCH 53:2459-2468(2012).
- Tamm, T; et al. Plasmids with E2 epitope tags: tagging modules for N- and C-terminal PCR-based gene targeting in both budding and fission yeast, and inducible expression vectors for fission yeast. YEAST 26:55-66(2009).
