NLRC4
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Official Full Name
NLR family, CARD domain containing 4 -
Overview
In C. elegans, Ced4 binds and activates Ced3, an apoptotic initiator caspase, via caspase-associated recruitment domains (CARDs). Human Ced4 homologs include APAF1 (MIM 602233), NOD1/CARD4 (MIM 605980), and NOD2/CARD15 (MIM 605956). These proteins have at least 1 N-terminal CARD domain followed by a centrally located nucleotide-binding domain (NBD or NACHT) and a C-terminal regulatory domain, found only in mammals, that contains either WD40 repeats or leucine-rich repeats (LRRs). CARD12 is a member of the Ced4 family and can induce apoptosis. -
Synonyms
NLRC4;NLR family, CARD domain containing 4;CARD12, caspase recruitment domain family, member 12;NLR family CARD domain-containing protein 4;CLAN;CLAN1;CLANA;CLANB;CLANC;CLAND;CLR2.1;ipaf;NOD like receptor C4;nucleotide binding oligomerizatio
Recombinant Proteins
- Mouse
- Human
- Mammalian Cell
- Wheat Germ
- HEK293
- His
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NLRC4-10714M | Recombinant Mouse NLRC4 Protein | Mammalian Cell | Mouse | His |
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| NLRC4-1317H | Recombinant Human NLRC4 Protein, GST-Tagged | Wheat Germ | Human | GST |
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| NLRC4-815H | Recombinant Human NLRC4 | Mammalian Cell | Human | His |
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| NLRC4-3805HCL | Recombinant Human NLRC4 293 Cell Lysate | HEK293 | Human | Non |
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| NLRC4-3639H | Recombinant Human NLRC4 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| NLRC4-3639H-B | Recombinant Human NLRC4 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| NLRC4-6093M | Recombinant Mouse NLRC4 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| NLRC4-6093M-B | Recombinant Mouse NLRC4 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
NLRC4 involved in several pathways and played different roles in them. We selected most pathways NLRC4 participated on our site, such as NOD-like receptor signaling pathway,Salmonella infection,Legionellosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with NLRC4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Salmonella infection | CASP1,IFNG,ACTB,ARPC5B,MAPK11,CCL3L1,ACTG1,TLR4BA,DYNC1I2A,KLC2 |
| NOD-like receptor signaling pathway | Ccl12,BIRC3,NAIP7,MAPK11,NFKB1,NFKBIA,IL18,CCL5,CASP8,NFKBIB |
| Legionellosis | CXCL3,TNF,ITGB2L,RELA,ITGAM,SAR1B,HBS1L,NAIP1,TLR5,IL-8 |
Protein Function
NLRC4 has several biochemical functions, for example, ATP binding,cysteine-type endopeptidase inhibitor activity,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NLRC4 itself. We selected most functions NLRC4 had, and list some proteins which have the same functions with NLRC4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| identical protein binding | PACSIN2,AGXT2,LZTFL1,SOD2,COL2A1,SNCAIP,SYNE1,TPD52L1,NQO1,SMAD1 |
| protein binding | TRIM22,RG9MTD1,FBXW5,APOBEC2B,GYG1,FOSL2,CPNE6,RPL23A,NIPBL,OSBPL2 |
| cysteine-type endopeptidase inhibitor activity | BIRC5B,NAIP1,BIRC5A,CTLA2B,CST3,CARD18,CARD16,HRG,STFA2,PTTG1 |
| magnesium ion binding | TSSK1,ILVBL,CIB4,ABL2,IMPA1,NUAK2,DIS3L2,PPA1,MTHFD2,IMPAD1 |
| ubiquitin-protein transferase activity | PRKCQ,RNF43,TRIM36,TRAF4B,TOPORS,UBA7,UBE3C,TRIM71,TRIM9,WWP2 |
| ATP binding | WARS2,SNRKB,STRADA,EIF2AK2,QARS,ITPK1,STK25B,NVL,TP53RK,NME3 |
| protein homodimerization activity | MIXL1,C16orf89,BCL2L10,ANO2,HLA-G,CHMP4A,PGCP,SLC39A13,SMAGP,IRAK2 |
Interacting Protein
NLRC4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NLRC4 here. Most of them are supplied by our site. Hope this information will be useful for your research of NLRC4.
CASP1;PYCARD;CASP8
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References
- Lockner, JW; Eubanks, LM; et al. Flagellin as Carrier and Adjuvant in Cocaine Vaccine Development. MOLECULAR PHARMACEUTICS 12:653-662(2015).
- Lopez-Yglesias, AH; Zhao, X; et al. Flagellin Induces Antibody Responses through a TLR5-and Inflammasome-Independent Pathway. JOURNAL OF IMMUNOLOGY 192:1587-1596(2014).
