NLN
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Official Full Name
neurolysin (metallopeptidase M3 family) -
Overview
This gene encodes a member of the metallopeptidase M3 protein family that cleaves neurotensin at the Pro10-Tyr11 bond, leading to the formation of neurotensin(1-10) and neurotensin(11-13). The encoded protein is likely involved in the termination of the neurotensinergic signal in the central nervous system and in the gastrointestinal tract. -
Synonyms
NLN;neurolysin (metallopeptidase M3 family);AGTBP, angiotensin binding protein;neurolysin, mitochondrial;KIAA1226;endopeptidase 24.16;microsomal endopeptidase;neurotensin endopeptidase;angiotensin binding protein;angiotensin-binding protein;mit
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Mammalian Cell
- E. coli
- HEK293
- Mammalian cells
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
- GST
Involved Pathway
NLN involved in several pathways and played different roles in them. We selected most pathways NLN participated on our site, such as Renin-angiotensin system, which may be useful for your reference. Also, other proteins which involved in the same pathway with NLN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Renin-angiotensin system | ACE2,THOP1,KLK1,CTSA,ACE,MAS1,KLK1B22,KLK1B8,REN,KLK1B1 |
Protein Function
NLN has several biochemical functions, for example, metal ion binding,metalloendopeptidase activity,peptide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NLN itself. We selected most functions NLN had, and list some proteins which have the same functions with NLN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metalloendopeptidase activity | XRCC6BP1,YBEY,MMP11,C6AST1,ADAMTS2,BMP1B,HE1B,C6AST3,TLL1,UQCRC2 |
| peptide binding | GNRHR1,TPP1,CCKAR,NPFFR1,QRFPR,OXTRL,PPYR1,NPFFR1L2,ANPEPA,NPFFR2.1 |
| metal ion binding | XPA,AMPD1,LACTB2,ZNF215,ZNF865,CTDSPL,PDXK,RBM22,CYP3A25,ZFPM2A |
Interacting Protein
NLN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NLN here. Most of them are supplied by our site. Hope this information will be useful for your research of NLN.
Dicer1;NCAPD3;DYNLL1;CBX1;HIF1A;Tnks2;Naa11;Eea1;RASSF8;ZNF526;RUFY1;MRPL9;Calml3;Fign;KLC4;GAR1;Cetn2
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References
- El-Ghonaimy, EA; El-Shinawi, M; et al. Positive lymph-node breast cancer patients - activation of NF-kappa B in tumor-associated leukocytes stimulates cytokine secretion that promotes metastasis via C-C chemokine receptor CCR7. FEBS Journal 282:271-282(2015).
- Antunes, SLG; Chimelli, L; et al. Histopathological examination of nerve samples from pure neural leprosy patients: obtaining maximum information to improve diagnostic efficiency. MEMORIAS DO INSTITUTO OSWALDO CRUZ 107:246-253(2012).
