NKX2-1
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Official Full Name
NK2 homeobox 1 -
Overview
NK2 homeobox 1 (NKX2-1), also known as thyroid transcription factor 1 (TTF-1), is a protein which in humans is encoded by the NKX2-1 gene. This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TFF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription. -
Synonyms
NKX2-1;NK2 homeobox 1;BCH, benign chorea , NKX2A, thyroid transcription factor 1 , TITF1;homeobox protein Nkx-2.1;TTF 1;TTF1;NK-2 homolog A;thyroid nuclear factor 1;thyroid transcription factor 1;homeobox protein NK-2 homolog A;BCH;BHC;NK-2
Recombinant Proteins
- Mouse
- Human
- Chicken
- E.coli
- Mammalian Cells
- Wheat Germ
- Protein Conjugation
- In Vitro Cell Free System
- His
- Non
- GST
- His&Myc
- His&GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NKX2-1-10697M | Recombinant Mouse NKX2-1 Protein, His-tagged | E.coli | Mouse | His | ||
| NKX2-1-226H | Recombinant Human NK2 Homeobox 1 | E.coli | Human | Non |
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| NKX2-1-6184C | Recombinant Chicken NKX2-1 | Mammalian Cells | Chicken | His |
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| NKX2-1-01H | Recombinant Human NKX2-1 Protein, GST-tagged | Wheat Germ | Human | GST | 1-371 |
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| NKX2-1-02H | Recombinant Human NKX2-1 Protein, GST-tagged | Wheat Germ | Human | GST | 56-147 |
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| NKX2-1-2824H | Recombinant Human NKX2-1 Protein, His-tagged, OVA Conjugated | Protein Conjugation | Human | His | Val13-Gly28 |
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| NKX2-1-3277H | Recombinant Human NKX2-1 protein, His&Myc-tagged | E.coli | Human | His&Myc | 1-371aa |
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| NKX2-1-384H | Recombinant Human NKX2-1 Protein, His&GST-tagged | E.coli | Human | His&GST | Ala40-Pro111 |
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| NKX2-1-5133H | Recombinant Human NKX2-1 Protein (Ala40-Pro111), N-GST tagged | E.coli | Human | GST | Ala40-Pro111 |
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| NKX2-1-6855HF | Recombinant Full Length Human NKX2-1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 371 amino acids |
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Involved Pathway
NKX2-1 involved in several pathways and played different roles in them. We selected most pathways NKX2-1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with NKX2-1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
NKX2-1 has several biochemical functions, for example, DNA binding,RNA polymerase II regulatory region DNA binding,RNA polymerase II regulatory region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NKX2-1 itself. We selected most functions NKX2-1 had, and list some proteins which have the same functions with NKX2-1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription regulatory region DNA binding | ZFHX3,CALCOCO1,DHX36,FOXI1,BCL11AB,THRA,GATA6,BRCA1,TP63,KLF11 |
| intronic transcription regulatory region DNA binding | THRA |
| enzyme binding | PLCE1,MAPK14,JUN,CBX4,SLC27A2,CAD,GSTM4,PPP3CB,HDAC10,HDAC6 |
| intronic transcription regulatory region sequence-specific DNA binding | GRHL2,BCL6 |
| RNA polymerase II regulatory region sequence-specific DNA binding | LEF1,PRDM12B,ATF4B1,FOXK1,RXRB,ARHGAP35,NHLH2,ZNF812,ETV6,CGGBP1 |
| protein binding | ZBTB48,NGB,WBP2,LIMS3L,PPIH,FBXO33,PUS7L,TXNRD3,DVL3,PIH1D1 |
| RNA polymerase II regulatory region DNA binding | NPAS4,ATXN3L,TXK,PPARG,NCOA1 |
| sequence-specific DNA binding | RORAB,HOXA13A,IRX4,IRX3A,GATAD2AB,ZFP536,NR1D4B,HOXA13B,DBX2,HOXB10A |
| DNA binding | AEBP1,ZBTB8B,ESR2,ZKSCAN14,MCM2,ZNF550,RAD51L1,HER4.3,ZKSCAN5,FOXO1B |
Interacting Protein
NKX2-1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NKX2-1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NKX2-1.
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References
- Lindskog, C; Fagerberg, L; et al. The lung-specific proteome defined by integration of transcriptomics and antibody-based profiling. FASEB JOURNAL 28:5184-5196(2014).
- DeMaio, L; Buckley, ST; et al. Ligand-independent transforming growth factor-ss type I receptor signalling mediates type I collagen-induced epithelial-mesenchymal transition. JOURNAL OF PATHOLOGY 226:633-644(2012).
