NHP2L1
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Official Full Name
NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae) -
Overview
Originally named because of its sequence similarity to the Saccharomyces cerevisiae NHP2 (non-histone protein 2), this;protein appears to be a highly conserved nuclear protein that is a component of the (U4/U6.U5) tri-snRNP. It binds to;the 5 stem-loop of U4 snRNA. Two transcript variants encoding the same protein have been found for this gene. -
Synonyms
NHP2L1;NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae);non histone chromosome protein 2 (S. cerevisiae) like 1 , sperm specific antigen 1 , SSFA1;NHP2-like protein 1;15.5K;FA 1;small nuclear ribonucleoprotein 15.5kDa (U4/U6.U5);SNRNP15 5;SNU13;SPAG12;[U4/U6.U5] tri snRNP;High mobility group like nuclear protein 2 homolog 1;hSNU13;NHP2 non histone chromosome protein 2 like 1 (S. cerevisiae);NHP2L 1;NHPX;OTK27;sperm specific antigen 1;U4/U6.U5 tri-snRNP 15.5 kDa protein;non-histone chromosome protein 2-like 1;[U4/U6.U5] tri-snRNP 15.5 kD RNA binding protein;high mobility group-like nuclear protein 2 homolog 1;FA1;FA-1;SSFA1;SNRNP15-5
Recombinant Proteins
- Human
- Mouse
- Rat
- Cynomolgus
- E.coli
- Mammalian Cell
- HEK293
- Yeast
- His
- His&Fc&Avi
- Myc&DDK
Involved Pathway
NHP2L1 involved in several pathways and played different roles in them. We selected most pathways NHP2L1 participated on our site, such as Ribosome biogenesis in eukaryotes,Spliceosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with NHP2L1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Spliceosome | ALYREF,HNRNPM,CWC15,SNRPD3,SRSF1A,NHP2L1B,TTC6,NCBP1,SF3A3,SNRPB |
| Ribosome biogenesis in eukaryotes | UTP15,GNL3,REX1,NAT10,XRN2,WDR43,MPHOSPH10,RAN,UTP18,POP7 |
Protein Function
NHP2L1 has several biochemical functions, for example, ATPase binding,RNA binding,U3 snoRNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NHP2L1 itself. We selected most functions NHP2L1 had, and list some proteins which have the same functions with NHP2L1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| U4 snRNA binding | DDX39B,PRPF31,SART3,PRPF4 |
| poly(A) RNA binding | RBMX,MRPL54,DHX30,FCF1,JUN,ZNFX1,KPNA2,MYH9,LTA4H,MRPL3 |
| contributes_to snoRNA binding | NUFIP1 |
| U3 snoRNA binding | ISG20,DIEXF |
| protein binding | FRMPD1,SGPL1,PPP4R4,KRTAP4-11,ZYX,DUSP7,FAM53C,RPS6KA1,PPP1R15A,SLC22A6 |
| ATPase binding | TOR1AIP2,METTL21A,SDF2L1,GABARAPL2,SVIP,ZNHIT6,ATPIF1B,ABCA1,PEX19,ATP6V1G1 |
| RNA binding | NABP1,SETD1BA,CPSF2,RBM15B,ELAVL1,NSUN3,EIF4B,SRSF10,FXR1,TRIM32 |
| U4atac snRNA binding | PRPF31 |
Interacting Protein
NHP2L1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NHP2L1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NHP2L1.
VCAM1;gag;NUFIP1;EPB41;Ruvbl1;Prpf8;Nhp2l1;Ruvbl2;TRAF6;CHST1;XRCC6;CDKN2C;RBM10;GTF3C1;SNW1
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References
- Benaglio, P; San Jose, PF; et al. Mutational screening of splicing factor genes in cases with autosomal dominant retinitis pigmentosa. MOLECULAR VISION 20:843-851(2014).
- Docherty, LE; Rezwan, FI; et al. Genome-wide DNA methylation analysis of patients with imprinting disorders identifies differentially methylated regions associated with novel candidate imprinted genes. JOURNAL OF MEDICAL GENETICS 51:229-238(2014).
