NGB
-
Official Full Name
neuroglobin -
Overview
This gene encodes an oxygen-binding protein that is distantly related to members of the globin gene family. It is highly conserved among other vertebrates. It is expressed in the central and peripheral nervous system where it may be involved in increasing oxygen availability and providing protection under hypoxic/ischemic conditions. -
Synonyms
NGB;neuroglobin
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Chicken
- Rat
- Zebrafish
- E.coli
- Mammalian Cells
- HEK293
- His
- Non
- GST
- DDK
- Myc
- Avi
- Fc
- SUMO
Involved Pathway
NGB involved in several pathways and played different roles in them. We selected most pathways NGB participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with NGB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
NGB has several biochemical functions, for example, heme binding,metal ion binding,oxygen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NGB itself. We selected most functions NGB had, and list some proteins which have the same functions with NGB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SIRT2,CDC73,ZMYND11,AP1G2,C5,TM4SF4,LGALS13,RRM1,TRPV4,ANKS4B |
| oxygen transporter activity | HBE,CYGB2,HBAA,IPCEF1,HBB,HBG1,XGB,HBAD,HBA1,HBD |
| heme binding | CYP1B1,PTGS1,HBAE3,CYP7B1,CYP3C1L2,CYP1C1,CYP2AA7,PGRMC1,MB,SDHDB |
| metal ion binding | HBBE2,ZFPL1,NR1D1,CDK5RAP1,GNAQ,ZFYVE28,NADK,EYA1,CACNA2D4,ZNF596 |
| oxygen binding | CYP2C37,CYP2D6,HBBE2,CYP2C19,CYP2P7,HBA-X,HBG2,CYP2Y3,CYP2J6,CYP2AD3 |
Interacting Protein
NGB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NGB here. Most of them are supplied by our site. Hope this information will be useful for your research of NGB.
TDO2;REL;VAC14;C1orf94;CCDC36;L3MBTL3
Resources
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References
- Lan, WB; Lin, JH; et al. Overexpressing neuroglobin improves functional recovery by inhibiting neuronal apoptosis after spinal cord injury. BRAIN RESEARCH 1562:100-108(2014).
- Raida, Z; Hundahl, CA; et al. Neuroglobin Over Expressing Mice: Expression Pattern and Effect on Brain Ischemic Infarct Size. PLOS ONE 8:-(2013).
